[HTML][HTML] Within the brain: the renin angiotensin system
LD Jackson, W Eldahshan, SC Fagan… - International journal of …, 2018 - mdpi.com
For many years, modulators of the renin angiotensin system (RAS) have been trusted by
clinicians for the control of essential hypertension. It was recently demonstrated that these …
clinicians for the control of essential hypertension. It was recently demonstrated that these …
AP-1 as a regulator of cell life and death
E Shaulian, M Karin - Nature cell biology, 2002 - nature.com
The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation,
transformation and death. Using mice and cells lacking AP-1 components, the target-genes …
transformation and death. Using mice and cells lacking AP-1 components, the target-genes …
Excitatory amino acids as a final common pathway for neurologic disorders
SA Lipton, PA Rosenberg - New England Journal of Medicine, 1994 - Mass Medical Soc
In many neurologic disorders, injury to neurons may be caused at least in part by
overstimulation of receptors for excitatory amino acids, including glutamate and aspartate …
overstimulation of receptors for excitatory amino acids, including glutamate and aspartate …
AP-1 function and regulation
AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors
composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common …
composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common …
Apoptosis. Its significance in cancer and cancer therapy
JFR Kerr, CM Winterford, BV Harmon - Cancer, 1994 - Wiley Online Library
Apoptosis is a distinct mode of cell death that is responsible for deletion of cells in normal
tissues; it also occurs in specific pathologic contexts. Morphologically, it involves rapid …
tissues; it also occurs in specific pathologic contexts. Morphologically, it involves rapid …
AP-1 in cell proliferation and survival
E Shaulian, M Karin - Oncogene, 2001 - nature.com
A plethora of physiological and pathological stimuli induce and activate a group of DNA
binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF …
binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF …
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Bcl-2 inhibits most types of apoptotic cell death, implying a common mechanism of lethality.
Bcl-2 is localized to intracellular sites of oxygen free radical generation including …
Bcl-2 is localized to intracellular sites of oxygen free radical generation including …
Triggering and modulation of apoptosis by oxidative stress
J Chandra, A Samali, S Orrenius - Free radical biology and medicine, 2000 - Elsevier
Cell survival requires multiple factors, including appropriate proportions of molecular oxygen
and various antioxidants. Although most oxidative insults can be overcome by the cell's …
and various antioxidants. Although most oxidative insults can be overcome by the cell's …
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
Chronic infection with hepatitis C virus (HCV) is a common cause of liver cirrhosis and
cancer. We performed RNA sequencing in primary human hepatocytes activated with …
cancer. We performed RNA sequencing in primary human hepatocytes activated with …
Mechanisms and genes of cellular suicide
H Steller - Science, 1995 - science.org
Apoptosis is a morphologically distinct form of programmed cell death that plays a major role
during development, homeostasis, and in many diseases including cancer, acquired …
during development, homeostasis, and in many diseases including cancer, acquired …