A wide variety of normal and malignant cell types generate and release superoxide or
hydrogen peroxide in vitro either in response to specific cytokine/growth factor stimulus or …

This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

Postmenopausal osteoporosis, the most common bone disease in the developed world1, is
associated with estrogen deficiency. This deficiency induces increased generation and …

Activation of the proto-oncogene c-fos in the brain was described initially almost a decade
ago and represents one of the most studied immediate early genes in the brain. Transient c …

Programmed cell death (apoptosis) is an active process by which cells initiate their own self-
destruction. Growing evidence shows that this event is controlled by the activation of unique …

Genetically modified mice have provided important insights into the biological functions of
the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with …

Despite extensive adverse publicity, tobacco use continues in approximately 25% of all
pregnancies in the United States, overshadowing illicit drugs of abuse, including cocaine …

Cataract is a major ocular disease that causes blindness in many developing countries of
the world. It is well established that various factors such as oxidative stress, UV, and other …

In pugilistic parlance, the one-two punch is a devastating combination of blows, with the first
punch setting the stage and the second delivering the knock-out. This analogy can be …

By comparing mRNA species expressed in dexamethasone (DEX)–treated and untreated
murine thymocytes, we have identified a gene, glucocorticoid-induced leucine zipper (GILZ) …