Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.
S Grimm, MK Bauer, PA Baeuerle… - The Journal of cell …, 1996 - rupress.org
Among the many target genes of the transcription factor NF-kappaB are p53 and c-myc, both
of which are involved in apoptosis. This prompted us to investigate the role of NF-kappaB in …
of which are involved in apoptosis. This prompted us to investigate the role of NF-kappaB in …
Apoptosis in target organs of hypertension
P Hamet, L Richard, TV Dam, E Teiger, SN Orlov… - …, 1995 - Am Heart Assoc
Apoptosis or programmed cell death frequently parallels abnormalities in cell proliferation
and differentiation. As hypertrophy/hyperplasia or remodeling occurs in organs affected by …
and differentiation. As hypertrophy/hyperplasia or remodeling occurs in organs affected by …
Induction of apoptosis by c-Fos protein
GA Preston, TT Lyon, Y Yin, JE Lang… - … and Cellular Biology, 1996 - Am Soc Microbiol
The role of c-Fos in apoptosis was examined in two Syrian hamster embryo cell lines (sup+ I
and sup− II) and a human colorectal carcinoma cell line (RKO), using the chimeric Fos …
and sup− II) and a human colorectal carcinoma cell line (RKO), using the chimeric Fos …
Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation
K Kobayashi, M Hatano, M Otaki… - Proceedings of the …, 1999 - National Acad Sciences
The inhibitor of apoptosis (IAP) proteins form a highly conserved gene family that prevents
cell death in response to a variety of stimuli. Herein we describe a newly defined murine IAP …
cell death in response to a variety of stimuli. Herein we describe a newly defined murine IAP …
Oxidative stress and neurodegenerative disorders
AY Sun, YM Chen - Journal of biomedical science, 1998 - karger.com
Oxidative insults, whether over-excitation, excessive release of glutamate or ATP caused by
stroke, ischemia or inflammation, exposure to ionizing radiation, heavy-metal ions or …
stroke, ischemia or inflammation, exposure to ionizing radiation, heavy-metal ions or …
Apoptotic cell death in retinal degenerations
CE Remé, C Grimm, F Hafezi, A Marti… - Progress in retinal and eye …, 1998 - Elsevier
Apoptosis is a regulated mode of single cell death that involves gene expression in many
instances and occurs under physiological and pathological conditions in a large variety of …
instances and occurs under physiological and pathological conditions in a large variety of …
The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease
JCS Breitner, MD, MPH - Annual review of medicine, 1996 - annualreviews.org
▪ Abstract Risk factor intervention is a useful strategy for prevention of poorly understood
diseases. Fifteen studies have examined the relation of glucocorticoid and nonsteroid …
diseases. Fifteen studies have examined the relation of glucocorticoid and nonsteroid …
gThe Dorothy Russell Memorial Lecture* The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms
McIntosh, Saatman, Raghupathi… - Neuropathology and …, 1998 - Wiley Online Library
The mechanisms underlying secondary or delayed cell death following traumatic brain injury
(TBI) are poorly understood. Recent evidence from experimental models of TBI suggest that …
(TBI) are poorly understood. Recent evidence from experimental models of TBI suggest that …
Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.
GP Linette, Y Li, K RoTH… - Proceedings of the …, 1996 - National Acad Sciences
BCL-2-deficient T cells demonstrate accelerated cell cycle progression and increased
apoptosis following activation. Increasing the levels of BCL-2 retarded the G0--> S transition …
apoptosis following activation. Increasing the levels of BCL-2 retarded the G0--> S transition …
Apoptosis Induced by Transforming Growth Factor-β in Fetal Hepatocyte Primary Cultures: INVOLVEMENT OF REACTIVE OXYGEN INTERMEDIATES (∗)
Transforming growth factor-β (TGF-β), a growth regulator of fetal hepatocytes in primary
culture, also regulates death of these cells. Dose-response analysis showed that the TGF-β …
culture, also regulates death of these cells. Dose-response analysis showed that the TGF-β …