Among the many target genes of the transcription factor NF-kappaB are p53 and c-myc, both
of which are involved in apoptosis. This prompted us to investigate the role of NF-kappaB in …

Apoptosis or programmed cell death frequently parallels abnormalities in cell proliferation
and differentiation. As hypertrophy/hyperplasia or remodeling occurs in organs affected by …

The role of c-Fos in apoptosis was examined in two Syrian hamster embryo cell lines (sup+ I
and sup− II) and a human colorectal carcinoma cell line (RKO), using the chimeric Fos …

The inhibitor of apoptosis (IAP) proteins form a highly conserved gene family that prevents
cell death in response to a variety of stimuli. Herein we describe a newly defined murine IAP …

Oxidative insults, whether over-excitation, excessive release of glutamate or ATP caused by
stroke, ischemia or inflammation, exposure to ionizing radiation, heavy-metal ions or …

Apoptosis is a regulated mode of single cell death that involves gene expression in many
instances and occurs under physiological and pathological conditions in a large variety of …

▪ Abstract Risk factor intervention is a useful strategy for prevention of poorly understood
diseases. Fifteen studies have examined the relation of glucocorticoid and nonsteroid …

The mechanisms underlying secondary or delayed cell death following traumatic brain injury
(TBI) are poorly understood. Recent evidence from experimental models of TBI suggest that …

BCL-2-deficient T cells demonstrate accelerated cell cycle progression and increased
apoptosis following activation. Increasing the levels of BCL-2 retarded the G0--> S transition …

Transforming growth factor-β (TGF-β), a growth regulator of fetal hepatocytes in primary
culture, also regulates death of these cells. Dose-response analysis showed that the TGF-β …