The premise of capsid assembly modulators towards eliminating HBV persistence
Introduction The burden of chronic hepatitis B virus (HBV) results in almost a million deaths
per year. The most common treatment for chronic hepatitis B infection is long-term …
per year. The most common treatment for chronic hepatitis B infection is long-term …
Mechanism of interferon alpha therapy for chronic hepatitis B and potential approaches to improve its therapeutic efficacy
Hepatitis B virus (HBV) chronically infects 296 million people worldwide and causes more
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles
H Vanrusselt, DB Kum, V Taverniti, C Liu… - Journal of …, 2023 - Am Soc Microbiol
Capsid assembly modulators (CAMs) are a novel class of therapeutic small molecules with
the potential to address the continued global challenge posed by chronic hepatitis B (CHB) …
the potential to address the continued global challenge posed by chronic hepatitis B (CHB) …
Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation
JM Berke, Y Tan, S Sauviller, D Wu, K Zhang… - Journal of …, 2024 - Am Soc Microbiol
Capsid assembly is critical in the hepatitis B virus (HBV) life cycle, mediated by the viral core
protein. Capsid assembly is the target for new anti-viral therapeutics known as capsid …
protein. Capsid assembly is the target for new anti-viral therapeutics known as capsid …
Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein
D Kornyeyev, Z Song, S Eng, C Soulette… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Capsid assembly mediated by hepatitis B virus (HBV) core protein (HBc) is an essential part
of the HBV replication cycle, which is the target for different classes of capsid assembly …
of the HBV replication cycle, which is the target for different classes of capsid assembly …
A novel hepatitis B virus capsid assembly modulator QL-007 inhibits HBV replication and infection through altering capsid assembly
J Xi, Z Gu, C Sun, Z Chen, T Zhang, R Chen, T Liu… - Antiviral Research, 2023 - Elsevier
The core protein allosteric modulators (CpAMs) have shown great potential as highly
effective antiviral drugs against hepatitis B virus (HBV) in preclinical studies and clinical …
effective antiviral drugs against hepatitis B virus (HBV) in preclinical studies and clinical …
Discovery of carboxyl-containing heteroaryldihydropyrimidine derivatives as novel HBV capsid assembly modulators with significantly improved metabolic stability
S Zhao, Y Wang, X Zhang, L Qiao, S Wang… - RSC Medicinal …, 2023 - pubs.rsc.org
Interfering with the assembly of hepatitis B virus (HBV) capsid is a promising approach for
treating chronic hepatitis B (CHB). In order to enhance the metabolic stability and reduce the …
treating chronic hepatitis B (CHB). In order to enhance the metabolic stability and reduce the …
[HTML][HTML] CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1
V Taverniti, L Meiss-Heydmann, C Gadenne… - JHEP Reports, 2024 - Elsevier
Background & aims Chronic HBV infection is the leading cause of liver disease and
hepatocellular carcinoma. The improvement of antiviral therapies remains an unmet medical …
hepatocellular carcinoma. The improvement of antiviral therapies remains an unmet medical …
Robust isolation protocol for mouse leukocytes from blood and liver resident cells for immunology research
D De Pooter, B De Clerck, K Dockx, D De Santis… - PloS one, 2024 - journals.plos.org
Research on liver-related conditions requires a robust and efficient method to purify viable
hepatocytes, lymphocytes and all other liver resident cells, such as Kupffer or liver …
hepatocytes, lymphocytes and all other liver resident cells, such as Kupffer or liver …
New tricks for old molecules: A newly discovered modality for CAMs may yet lead to an HBV cure
A Zlotnick, S Nair, SP Katen - Hepatology, 2023 - journals.lww.com
New tricks for old molecules: A newly discovered modality fo... : Hepatology New tricks for old
molecules: A newly discovered modality for CAMs may yet lead to an HBV cure : Hepatology …
molecules: A newly discovered modality for CAMs may yet lead to an HBV cure : Hepatology …