Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …

Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Protein phosphatases are the essential opposite to protein kinases; together, these enzymes
regulate all protein phosphorylation and most cellular processes. To better understand the …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular
functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human …

Diabetes mellitus are complex, multi‐organ metabolic pathologies characterized by
hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT …

PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in
HER2 signaling in breast tumorigenesis. Efforts to develop therapeutic inhibitors of PTP1B …

Cancer, more than any other human disease, now has a surfeit of potential molecular targets
poised for therapeutic exploitation. Currently, a number of attractive and validated cancer …

Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous
cellular processes, and several PTPs have been validated as therapeutic targets for human …

Abstract Protein Tyrosine Phosphatase 1B (PTP1B), as one of the most important members
in PTP superfamily, plays a vital role in conducting various cellular functions. So far, PTP1B …