Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …

Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which
requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening …

Background: ET-1 (endothelin-1) is implicated in the pathophysiology of heart failure and
renal disease. Its prognostic importance and relationship with kidney function in patients …

Congestive heart failure (HF) is a complex disease state characterized by impaired
ventricular function and insufficient peripheral blood supply. The resultant reduced blood …

Proteases are stored in very large amounts within abundant cytoplasmic granules of mast
cells (MCs), and in lower amounts in basophils. These proteases are stored in their active …

The spread of SARS‐CoV‐2, along with the lack of targeted medicaments, encouraged
research of existing drugs for repurposing. The rapid response to SARS‐CoV‐2 infection …

Heart failure is a complex medical syndrome that is attributed to a number of risk factors;
nevertheless, its clinical presentation is quite similar among the different etiologies. Heart …

G protein-coupled receptors (GPCRs) mediate cellular responses to diverse extracellular
stimuli that play vital roles in the regulation of biology, including behavior. Abnormal G …

A double‐hit biological alteration involving exposure to oxygen deprivation in hypothyroid
condition may exacerbate cellular oxidative and inflammatory disturbances comparative to a …

Hypertension-induced ventricular and vascular remodeling causes myocardial infarction,
heart failure, and sudden death. Most available pharmaceutical products used to treat …