A systematic review of the applications of artificial intelligence and machine learning in autoimmune diseases
IS Stafford, M Kellermann, E Mossotto, RM Beattie… - NPJ digital …, 2020 - nature.com
Autoimmune diseases are chronic, multifactorial conditions. Through machine learning (ML),
a branch of the wider field of artificial intelligence, it is possible to extract patterns within …
a branch of the wider field of artificial intelligence, it is possible to extract patterns within …
Clinically isolated syndromes
DH Miller, DT Chard, O Ciccarelli - The Lancet Neurology, 2012 - thelancet.com
Clinically isolated syndrome (CIS) is a term that describes a first clinical episode with
features suggestive of multiple sclerosis (MS). It usually occurs in young adults and affects …
features suggestive of multiple sclerosis (MS). It usually occurs in young adults and affects …
A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis
A Ramesh, RD Schubert… - Proceedings of the …, 2020 - National Acad Sciences
Central nervous system B cells have several potential roles in multiple sclerosis (MS):
secretors of proinflammatory cytokines and chemokines, presenters of autoantigens to T …
secretors of proinflammatory cytokines and chemokines, presenters of autoantigens to T …
T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention
J Van Langelaar, RM van der Vuurst de Vries… - Brain, 2018 - academic.oup.com
Abstract Interleukin-17-expressing CD4+ T helper 17 (Th17) cells are considered as critical
regulators of multiple sclerosis disease activity. However, depending on the species and pro …
regulators of multiple sclerosis disease activity. However, depending on the species and pro …
Multiple sclerosis: risk factors, prodromes, and potential causal pathways
Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of
MS is not yet known, although epidemiological data indicate that both genetic and …
MS is not yet known, although epidemiological data indicate that both genetic and …
From the prodromal stage of multiple sclerosis to disease prevention
RA Marrie, M Allegretta, LF Barcellos, B Bebo… - Nature Reviews …, 2022 - nature.com
A prodrome is an early set of signs or symptoms that indicate the onset of a disease before
more typical symptoms develop. Prodromal stages are well recognized in some neurological …
more typical symptoms develop. Prodromal stages are well recognized in some neurological …
The genetics of multiple sclerosis: an up‐to‐date review
Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system
that often leads to disability in young adults. Treatment options are limited and often only …
that often leads to disability in young adults. Treatment options are limited and often only …
Body fluid biomarkers in multiple sclerosis
M Comabella, X Montalban - The Lancet Neurology, 2014 - thelancet.com
Biomarkers can be thought of as multifaceted indicators of healthy status or of pathological
disorders. The study of multiple sclerosis can benefit from the use of biomarkers because of …
disorders. The study of multiple sclerosis can benefit from the use of biomarkers because of …
The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?
HL Weiner - Annals of Neurology: Official Journal of the …, 2009 - Wiley Online Library
Multiple sclerosis is (MS) a T‐cell autoimmune disease characterized by a relapsing‐
remitting followed by a progressive phase. Relapses are driven by the adaptive immune …
remitting followed by a progressive phase. Relapses are driven by the adaptive immune …
MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood
MB Cox, MJ Cairns, KS Gandhi, AP Carroll… - PloS one, 2010 - journals.plos.org
It is well established that Multiple Sclerosis (MS) is an immune mediated disease. Little is
known about what drives the differential control of the immune system in MS patients …
known about what drives the differential control of the immune system in MS patients …