Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

E Evangelou, HR Warren, D Mosen-Ansorena… - Nature …, 2018 - nature.com
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …

Gentiopicroside Produces Endothelium‐Independent Vasodilation by Deactivating the PI3K/Akt/Rho‐Kinase Pathway in Isolated Rat Thoracic Aorta

S Xing, F Nong, J Qin, H Huang… - BioMed Research …, 2021 - Wiley Online Library
Gentiopicroside (GPS), a main active secoiridoid glucoside derived from the roots of
perennial herbs in the Gentianaceae family, has antispasmodic and relaxant effects …

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

E Evangelou, HR Warren, D Mosen-Ansorena… - BioRxiv, 2017 - biorxiv.org
High blood pressure is the foremost heritable global risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits to date (systolic …

[HTML][HTML] Effects of sevoflurane on left ventricular function by speckle-tracking echocardiography in coronary bypass patients: A randomized trial

C Gong, X Zhou, Y Fang, Y Zhang, L Zhu… - Journal of Biomedical …, 2024 - ncbi.nlm.nih.gov
The present study aimed to dynamically observe the segmental and global myocardial
movements of the left ventricle during coronary artery bypass grafting by transesophageal …

[HTML][HTML] Terlipressin relieves intestinal and renal injuries induced by acute mesenteric ischemia via PI3K/Akt pathway

ZM Liu, HJ Lai, XD Guan, SH Wen… - … Journal of Medical …, 2020 - ncbi.nlm.nih.gov
Background: To date, the effect of vasopressin on organ damages after acute mesenteric
ischemia (MI) remains poorly understood. Aims: To investigate the effect of terlipressin, a …

[HTML][HTML] Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas

S Yang, Y Liu, S Huang, F Jin, F Qi - BMC anesthesiology, 2021 - Springer
Background The mechanism of volatile anesthetics on vascular smooth muscle (VSM)
contraction in the setting of diabetes mellitus (DM) remains unclear. The current study was …