Neurotrophins are a collection of structurally and functionally related proteins. They play
important roles in many aspects of neural development, survival, and plasticity. Traumatic …

Nerve growth factor (NGF) promotes the survival and differentiation of neurons. NGF is
initially synthesized as a precursor, proNGF, which is the predominant form in the central …

Nerve infiltration is essential to prostate cancer progression, but the mechanism by which
nerves are attracted to prostate tumors remains unknown. We report that the precursor of …

Evidence from human neuropathological studies indicates that the levels of the
neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are …

Aging is a physiological event dependent on multiple pathways that are linked to lifespan
and processes leading to cognitive decline. This process represents the major risk factor for …

In normal adult retinas, NGF receptor TrkA is expressed in retinal ganglion cells (RGC),
whereas glia express p75 NTR. During retinal injury, endogenous NGF, TrkA, and p75 NTR …

The common neurotrophin receptor (p75NTR) regulates various functions in the developing
and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and …

Alzheimer's disease (AD) causes dementia in both young and old people affecting more
than 40 million people worldwide. The two neuropathological hallmarks of the disease …

Neurotrophins are established molecular mediators of neuronal plasticity in the adult brain.
We analyzed the impact of aging on brain-derived neurotrophic factor (BDNF) and nerve …

Neurotrophins are a family of proteins that support neuronal proliferation, survival, and
differentiation in the central and peripheral nervous systems, and are regulators of neuronal …