The developing heart is formed of two tissue layers separated by an extracellular matrix
(ECM) that provides chemical and physical signals to cardiac cells. While deposition of …

Cardiac congenital disabilities are the most common organ malformations, but we still do not
understand how they arise in the human embryo. Moreover, although cardiovascular …

Heart development is a continuous process involving significant remodeling during
embryogenesis and neonatal stages. To date, several groups have used single-cell …

Aplasia cutis congenita (ACC) is a congenital epidermal defect of the midline scalp and has
been proposed to be due to a primary keratinocyte abnormality. Why it forms mainly at this …

Multi-lineage development from gastruloids is enabling unprecedented opportunities to
model and study human embryonic processes and is expected to accelerate ex vivo …

The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates
is still poorly understood. Here, we identified Prdm6 as an epigenetic modifier that …

In animal models, Nipbl deficiency phenocopies gene expression changes and birth defects
seen in Cornelia de Lange syndrome, the most common cause of which is Nipbl …

The neural crest (NC) is a multipotent and temporarily migratory cell population stemming
from the dorsal neural tube during vertebrate embryogenesis. Cardiac neural crest cells …

Axenfeld–Rieger syndrome (ARS) encompasses a group of developmental disorders that
affect the anterior segment of the eye, as well as systemic developmental defects in some …

The heterogeneity of functional cardiomyocytes arises during heart development, which is
essential to the complex and highly coordinated cardiac physiological function. Yet the …