Irinotecan: 25 years of cancer treatment
C Bailly - Pharmacological research, 2019 - Elsevier
Twenty-five years ago, the cytotoxic drug irinotecan (IRT) was first approved in Japan for the
treatment of cancer. For more than two decades, the IRT prodrug has largely contributed to …
treatment of cancer. For more than two decades, the IRT prodrug has largely contributed to …
[HTML][HTML] Anthocyanins: traditional uses, structural and functional variations, approaches to increase yields and products' quality, hepatoprotection, liver longevity, and …
HA Mohammed, RA Khan - International Journal of Molecular Sciences, 2022 - mdpi.com
Anthocyanins are water-soluble, colored compounds of the flavonoid class, abundantly
found in the fruits, leaves, roots, and other parts of the plants. The fruit berries are prime …
found in the fruits, leaves, roots, and other parts of the plants. The fruit berries are prime …
drug‐induced liver injury in the context of nonalcoholic fatty liver disease–a physiopathological and clinical integrated view
F Bessone, M Dirchwolf, MA Rodil… - Alimentary …, 2018 - Wiley Online Library
Background Nonalcoholic fatty disease (NAFLD) is the most common liver disease, since it
is strongly associated with obesity and metabolic syndrome pandemics. NAFLD may affect …
is strongly associated with obesity and metabolic syndrome pandemics. NAFLD may affect …
[HTML][HTML] Drug-induced fatty liver disease: Pathogenesis and treatment
Metabolic dysfunction-associated fatty liver disease (commonly known as MAFLD) impacts
global health in epidemic proportions, and the resulting morbidity, mortality and economic …
global health in epidemic proportions, and the resulting morbidity, mortality and economic …
[HTML][HTML] Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism
Little is known about the impact of morphological disorders in distinct zones on metabolic
zonation. It was described recently that periportal fibrosis did affect the expression of CYP …
zonation. It was described recently that periportal fibrosis did affect the expression of CYP …
MRI assessment of ectopic fat accumulation in pancreas, liver and skeletal muscle in patients with obesity, overweight and normal BMI in correlation with the presence …
J Pieńkowska, B Brzeska, M Kaszubowski… - … syndrome and obesity …, 2019 - Taylor & Francis
Purpose: Obesity, defined as a body mass index (BMI) exceeding 30 kg/m2, is a serious
health problem, which can be called an epidemic on a global scale and is one of the most …
health problem, which can be called an epidemic on a global scale and is one of the most …
[HTML][HTML] Colorectal cancer: disease process, current treatment options, and future perspectives
Colorectal cancer (CRC) is one of the deadliest malignancies in the US, ranking fourth after
lung, prostate, and breast cancers, respectively, in general populations. It continues to be a …
lung, prostate, and breast cancers, respectively, in general populations. It continues to be a …
[HTML][HTML] Vitamin A intake forms resistance to hypervitaminosis A and affects the functional activity of the liver
A Bozhkov, I Ionov, N Kurhuzova, A Novikova… - Clinical Nutrition Open …, 2022 - Elsevier
Disruption of the exchange of copper ions in the body is accompanied by the development
of a number of pathologies and, most often, liver fibrosis. Ito cells, which deposit vitamin A …
of a number of pathologies and, most often, liver fibrosis. Ito cells, which deposit vitamin A …
[HTML][HTML] Cell models and omics techniques for the study of nonalcoholic fatty liver disease: focusing on stem cell-derived cell models
M Pelechá, E Villanueva-Bádenas, E Timor-López… - Antioxidants, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in
western countries. The molecular mechanisms leading to NAFLD are only partially …
western countries. The molecular mechanisms leading to NAFLD are only partially …
[HTML][HTML] New avenues for treatment and prevention of drug-induced steatosis and steatohepatitis: much more than antioxidants
Drug-induced lipid accumulation in the liver may induce two clinically relevant conditions,
drug-induced steatosis (DIS) and drug-induced steatohepatitis (DISH). The list of drugs that …
drug-induced steatosis (DIS) and drug-induced steatohepatitis (DISH). The list of drugs that …