Twenty-five years ago, the cytotoxic drug irinotecan (IRT) was first approved in Japan for the
treatment of cancer. For more than two decades, the IRT prodrug has largely contributed to …

Anthocyanins are water-soluble, colored compounds of the flavonoid class, abundantly
found in the fruits, leaves, roots, and other parts of the plants. The fruit berries are prime …

Background Nonalcoholic fatty disease (NAFLD) is the most common liver disease, since it
is strongly associated with obesity and metabolic syndrome pandemics. NAFLD may affect …

Metabolic dysfunction-associated fatty liver disease (commonly known as MAFLD) impacts
global health in epidemic proportions, and the resulting morbidity, mortality and economic …

Little is known about the impact of morphological disorders in distinct zones on metabolic
zonation. It was described recently that periportal fibrosis did affect the expression of CYP …

Purpose: Obesity, defined as a body mass index (BMI) exceeding 30 kg/m2, is a serious
health problem, which can be called an epidemic on a global scale and is one of the most …

Colorectal cancer (CRC) is one of the deadliest malignancies in the US, ranking fourth after
lung, prostate, and breast cancers, respectively, in general populations. It continues to be a …

Disruption of the exchange of copper ions in the body is accompanied by the development
of a number of pathologies and, most often, liver fibrosis. Ito cells, which deposit vitamin A …

Nonalcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in
western countries. The molecular mechanisms leading to NAFLD are only partially …

Drug-induced lipid accumulation in the liver may induce two clinically relevant conditions,
drug-induced steatosis (DIS) and drug-induced steatohepatitis (DISH). The list of drugs that …