Irinotecan: 25 years of cancer treatment

C Bailly - Pharmacological research, 2019 - Elsevier
Twenty-five years ago, the cytotoxic drug irinotecan (IRT) was first approved in Japan for the
treatment of cancer. For more than two decades, the IRT prodrug has largely contributed to …

[HTML][HTML] Anthocyanins: traditional uses, structural and functional variations, approaches to increase yields and products' quality, hepatoprotection, liver longevity, and …

HA Mohammed, RA Khan - International Journal of Molecular Sciences, 2022 - mdpi.com
Anthocyanins are water-soluble, colored compounds of the flavonoid class, abundantly
found in the fruits, leaves, roots, and other parts of the plants. The fruit berries are prime …

drug‐induced liver injury in the context of nonalcoholic fatty liver disease–a physiopathological and clinical integrated view

F Bessone, M Dirchwolf, MA Rodil… - Alimentary …, 2018 - Wiley Online Library
Background Nonalcoholic fatty disease (NAFLD) is the most common liver disease, since it
is strongly associated with obesity and metabolic syndrome pandemics. NAFLD may affect …

[HTML][HTML] Drug-induced fatty liver disease: Pathogenesis and treatment

TO Kolaric, V Nincevic, L Kuna, K Duspara… - Journal of clinical and …, 2021 - ncbi.nlm.nih.gov
Metabolic dysfunction-associated fatty liver disease (commonly known as MAFLD) impacts
global health in epidemic proportions, and the resulting morbidity, mortality and economic …

[HTML][HTML] Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism

M Albadry, S Höpfl, N Ehteshamzad, M König… - Scientific reports, 2022 - nature.com
Little is known about the impact of morphological disorders in distinct zones on metabolic
zonation. It was described recently that periportal fibrosis did affect the expression of CYP …

MRI assessment of ectopic fat accumulation in pancreas, liver and skeletal muscle in patients with obesity, overweight and normal BMI in correlation with the presence …

J Pieńkowska, B Brzeska, M Kaszubowski… - … syndrome and obesity …, 2019 - Taylor & Francis
Purpose: Obesity, defined as a body mass index (BMI) exceeding 30 kg/m2, is a serious
health problem, which can be called an epidemic on a global scale and is one of the most …

[HTML][HTML] Colorectal cancer: disease process, current treatment options, and future perspectives

AS Adebayo, K Agbaje, SK Adesina, O Olajubutu - Pharmaceutics, 2023 - mdpi.com
Colorectal cancer (CRC) is one of the deadliest malignancies in the US, ranking fourth after
lung, prostate, and breast cancers, respectively, in general populations. It continues to be a …

[HTML][HTML] Vitamin A intake forms resistance to hypervitaminosis A and affects the functional activity of the liver

A Bozhkov, I Ionov, N Kurhuzova, A Novikova… - Clinical Nutrition Open …, 2022 - Elsevier
Disruption of the exchange of copper ions in the body is accompanied by the development
of a number of pathologies and, most often, liver fibrosis. Ito cells, which deposit vitamin A …

[HTML][HTML] Cell models and omics techniques for the study of nonalcoholic fatty liver disease: focusing on stem cell-derived cell models

M Pelechá, E Villanueva-Bádenas, E Timor-López… - Antioxidants, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in
western countries. The molecular mechanisms leading to NAFLD are only partially …

[HTML][HTML] New avenues for treatment and prevention of drug-induced steatosis and steatohepatitis: much more than antioxidants

M Cataldi, V Citro, C Resnati, F Manco… - Advances in Therapy, 2021 - Springer
Drug-induced lipid accumulation in the liver may induce two clinically relevant conditions,
drug-induced steatosis (DIS) and drug-induced steatohepatitis (DISH). The list of drugs that …