Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds

M Erdem Büyükkiraz, Z Kesmen - Journal of applied …, 2022 - academic.oup.com
Antimicrobial peptides (AMPs) are compounds, which have inhibitory activity against
microorganisms. In the last decades, AMPs have become powerful alternative agents that …

Antimicrobial peptides: A new hope in biomedical and pharmaceutical fields

A Moretta, C Scieuzo, AM Petrone, R Salvia… - Frontiers in cellular …, 2021 - frontiersin.org
Antibiotics are essential drugs used to treat pathogenic bacteria, but their prolonged use
contributes to the development and spread of drug-resistant microorganisms. Antibiotic …

Lessons learned from clinical trials using antimicrobial peptides (AMPs)

GS Dijksteel, MMW Ulrich, E Middelkoop… - Frontiers in …, 2021 - frontiersin.org
Antimicrobial peptides (AMPs) or host defense peptides protect the host against various
pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory …

Role of metabolic endotoxemia in systemic inflammation and potential interventions

S Mohammad, C Thiemermann - Frontiers in immunology, 2021 - frontiersin.org
Diet-induced metabolic endotoxemia is an important factor in the development of many
chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents …

The immune functions of keratinocytes in skin wound healing

M Piipponen, D Li, NX Landén - International journal of molecular …, 2020 - mdpi.com
As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair
not only as structural cells but also exerting important immune functions. This review focuses …

Antibiofilm activity of host defence peptides: complexity provides opportunities

REW Hancock, MA Alford, EF Haney - Nature Reviews Microbiology, 2021 - nature.com
Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …

A new era of antibiotics: the clinical potential of antimicrobial peptides

K Browne, S Chakraborty, R Chen… - International journal of …, 2020 - mdpi.com
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health.
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …

Conductive Antibacterial Hemostatic Multifunctional Scaffolds Based on Ti3C2Tx MXene Nanosheets for Promoting Multidrug-Resistant Bacteria-Infected Wound …

L Zhou, H Zheng, Z Liu, S Wang, Z Liu, F Chen… - ACS …, 2021 - ACS Publications
Chronic bacterial-infected wound healing/skin regeneration remains a challenge due to
drug resistance and the poor quality of wound repair. The ideal strategy is combating …

Antimicrobial peptides as therapeutic agents: Opportunities and challenges

M Mahlapuu, C Björn, J Ekblom - Critical reviews in biotechnology, 2020 - Taylor & Francis
The rapid development of microbial resistance to conventional antibiotics has accelerated
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …

Emerging strategies to combat ESKAPE pathogens in the era of antimicrobial resistance: a review

MS Mulani, EE Kamble, SN Kumkar… - Frontiers in …, 2019 - frontiersin.org
The acronym ESKAPE includes six nosocomial pathogens that exhibit multidrug resistance
and virulence: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae …