Aurora kinase A, a synthetic lethal target for precision cancer medicine

PK Mou, EJ Yang, C Shi, G Ren, S Tao… - Experimental & Molecular …, 2021 - nature.com
Recent advances in high-throughput sequencing technologies and data science have
facilitated the development of precision medicine to treat cancer patients. Synthetic lethality …

Thyroid allostasis–adaptive responses of thyrotropic feedback control to conditions of strain, stress, and developmental programming

A Chatzitomaris, R Hoermann, JE Midgley… - Frontiers in …, 2017 - frontiersin.org
The hypothalamus–pituitary–thyroid feedback control is a dynamic, adaptive system. In
situations of illness and deprivation of energy representing type 1 allostasis, the stress …

Euthyroid sick syndrome

S Lee, AP Farwell - Comprehensive Physiology, 2011 - Wiley Online Library
In this review, we discuss the characteristics, pathophysiology, and therapeutic implications
of the euthyroid sick syndrome. Multiple mechanisms have been identified to contribute to …

Relationship between thyroid function and ICU mortality: a prospective observation study

F Wang, W Pan, H Wang, S Wang, S Pan, J Ge - Critical care, 2012 - Springer
Introduction Although nonthyroidal illness syndrome is considered to be associated with
adverse outcome in ICU patients, the performance of thyroid hormone levels in predicting …

The clinical use of thyroid function tests

GA Carvalho, CLS Perez, LS Ward - Arquivos Brasileiros de …, 2013 - SciELO Brasil
Laboratory tests are essential for the accurate diagnosis and cost-effective monitoring of
thyroid dysfunction. Hormone levels can only confirm a diagnosis when there is a high level …

Association of thyroid dysfunction and COVID-19: A systematic review and meta-analysis

M Darvishi, MR Nazer, H Shahali… - Frontiers in endocrinology, 2022 - frontiersin.org
This systematic review and meta-analysis was conducted to evaluate the effect of COVID-19
on thyroid function and the role of thyroid hormones alterations in predicting the severity of …

[HTML][HTML] Clinical concepts on thyroid emergencies

G Papi, SM Corsello, A Pontecorvi - Frontiers in endocrinology, 2014 - frontiersin.org
Objective: Thyroid-related emergencies are caused by overt dysfunction of the gland which
are so severe that require admission to intensive care units (ICU) frequently. Nonetheless, in …

[HTML][HTML] Centrality of G6PD in COVID-19: the biochemical rationale and clinical implications

Y Buinitskaya, R Gurinovich, CG Wlodaver… - Frontiers in …, 2020 - frontiersin.org
Introduction: COVID-19 is a novel and devastating disease. Its manifestations vary from
asymptomatic to lethal. Moreover, mortality rates differ based on underlying health …

Prognostic significance of nonthyroidal illness syndrome in critically ill adult patients with sepsis

R Padhi, S Kabi, BN Panda… - International journal of …, 2018 - journals.lww.com
Aim: This study was performed to investigate the association of non-thyroidal illness
syndrome (NTIS) with 28-day mortality in adults with sepsis. Methods: We performed a …

[HTML][HTML] Thyroid hormone profile in patients with acute coronary syndrome

FA Qari - Iranian Red Crescent Medical Journal, 2015 - ncbi.nlm.nih.gov
Background: Thyroid hormone has the a major role in the cardiovascular system function
and cardiac a As well as to maintain the cardiovascular homeostasis A slightly change ind …