Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …

Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

Left ventricular hypertrophy is a leading risk factor for cardiovascular morbidity and mortality.
Although reverse ventricular remodelling was long thought to be irreversible, evidence from …

Heart failure (HF) is a complex clinical syndrome characterized by the activation of at least
several neurohumoral pathways that have a common role in maintaining cardiac output and …

Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions
that results in structural and functional remodeling leading to subsequent impairment of …

Beta adrenergic receptors (βARs) mediate physiologic responses to the catecholamines
epinephrine and norepinephrine released by the sympathetic nervous system. While the …

Beta-blockers are widely used molecules that are able to antagonize β-adrenergic receptors
(ARs), which belong to the G protein-coupled receptor family and receive their stimulus from …

Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial
hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV …

Satellite glia are the major glial cells in sympathetic ganglia, enveloping neuronal cell
bodies. Despite this intimate association, the extent to which sympathetic functions are …

Cardiovascular diseases are the leading cause of mortality and morbidity worldwide and
account for more than 17.9 million deaths (World Health Organization report). Hypertension …