Tobacco and nicotine use are associated with disease susceptibility and progression.
Health challenges associated with nicotine and smoking include developmental delays …

Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Neuronal activity-regulated gene expression plays a crucial role in sculpting neural circuits
that underpin adaptive brain function. Transcriptional enhancers are now recognized as key …

Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …

Vocal production learning (“vocal learning”) is a convergently evolved trait in vertebrates. To
identify brain genomic elements associated with mammalian vocal learning, we integrated …

Human and non-human primates have strikingly similar genomes, but they strongly differ in
many brain-based processes (eg, behaviour and cognition). While the functions of protein …

Background Evolutionary conservation is an invaluable tool for inferring functional
significance in the genome, including regions that are crucial across many species and …

Drought stress poses a critical threat to global crop yields and sustainable agriculture. The
GASA genes are recognized for their pivotal role in stress tolerance and plant growth, but …

Although noncoding RNAs (ncRNAs) have been shown to regulate maladaptive
neuroadaptations that drive compulsive drug use, ncRNA-targeting therapeutics for …

Epigenetic gene regulation in the heterogeneous brain remains challenging to decipher with
current strategies. Bulk tissue analysis from pooled subjects reflects the average of cell-type …