Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells generated directly
from mature cells through the introduction of key transcription factors. iPSCs can be …

Background Precise genome editing via homology-directed repair (HDR) after double-
stranded DNA (dsDNA) cleavage facilitates functional genomic research and holds promise …

Investigations of CRISPR gene knockout editing profiles have contributed to enhanced
precision of editing outcomes. However, for homology-directed repair (HDR) in particular …

Human induced pluripotent stem cells (hiPSCs,,) are useful in disease modeling and drug
discovery, and they promise to provide a new generation of cell-based therapeutics. To date …

Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for
functional genomics, disease modeling, and regenerative medicine. However, low editing …

Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor
for valvulopathy and aortopathy. Here we report a genome-wide association scan of 466 …

Over a decade ago, a landmark study that reported derivation of induced Pluripotent Stem
Cells (iPSCs) by reprogramming fibroblasts has transformed stem cell research attracting …

CRISPR-Cas9 is a powerful genome editing technology, yet with off-target effects. Truncated
sgRNAs (17nt) have been found to decrease off-target cleavage without affecting on-target …

This may be the most exciting time ever for the field of tissue engineering and regenerative
medicine (TERM). After decades of progress, it has matured, integrated, and diversified into …