A complex pathogenesis involving several physiological systems is theorized to underline
the development of depressive disorders. Depression is accompanied by circadian …

Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …

Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …

Melatonin was discovered more than 60 years ago. Since then, several seminal discoveries
have allowed us to define its function as a neuroendocrine hormone and its molecular …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Simple Summary Membrane proteins are essential to all forms of life. Millions of membrane
proteins are found in the lipid membrane layer that surrounds cells, and in the lipid …

Background Ionizing radiations (IR) have widespread useful applications in our daily life;
however, they have unfavorable effects on reproductive health. Maintaining testicular health …

Breast cancer is the most common type of cancer. In the developmental stages of breast
cancer, estrogens are strongly involved. As estrogen synthesis is regulated by the enzyme …

This review concerns the current knowledge of melatonin and alcohol-related disorders.
Chronobiological effects of ethanol are related to melatonin suppression and in relation to …

Aging comes with gradual loss of functions that increase the vulnerability to disease,
senescence, and death. The mechanisms underlying these processes are linked to a …