Cytoplasmic dynein is involved in a wide variety of cellular functions. In addition to the
initially characterized form (MAP 1C/dynein 1), a second form of cytoplasmic dynein (dynein …

Neurotrophic factors and their receptors play a central role in neuronal survival. Since
neurons have a highly polarized morphology, target-derived neurotrophic factor signaling is …

Synaptic cargo trafficking is essential for synapse formation, function and plasticity. In order
to transport synaptic cargo, such as synaptic vesicle precursors, mitochondria …

Brain-derived neurotrophic factor (BDNF), secreted from target tissues, binds and activates
TrkB receptors, located on axonal terminals of the innervating neurons, and thereby initiates …

Neurons can specifically internalize macromolecules, such as trophic factors, lectins, toxins,
and other pathogens. Upon internalization in terminals, proteins can move retrogradely …

Long-distance axonal transport is critical to the maintenance and function of neurons.
Robust transport is ensured by the coordinated activities of multiple molecular motors acting …

The release of intercellular messengers from synaptic (SVs) and dense-core vesicles
(DCVs) constitutes the primary mechanism for communication between neighboring or …

Famine and viral infection, as well as interferon therapy have been reported to increase the
risk of developing bipolar disorder. In addition, almost 100 polymorphic genes have been …

Most of the long‐range intracellular movements of vesicles, organelles and other cargoes
are driven by microtubule (MT)‐based molecular motors. Cytoplasmic dynein, a multisubunit …

The mechanisms that regulate symmetric, proliferative divisions versus asymmetric,
neurogenic divisions of mammalian neural precursors are still not well understood. We …