Ion channels allow the flux of specific ions across biological membranes, thereby
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …

In recent years, the role of potassium channels in tumors has been intensively studied.
Potassium channel proteins are widely involved in various physiological and pathological …

Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological
subtypes of solid cancer; however, SCCs are derived from different organs with similar …

Modifications of the composition or organization of the cancer cell membrane seem to be a
promising targeted therapy. This approach can significantly enhance drug uptake or …

Background There is increasing evidence that mesenchymal stem cells (MSCs) help shape
the tumor microenvironment and promote tumor progression, and ion channels might play a …

Objectives Antiepileptic and antiarrhythmic drugs inhibit voltage-gated sodium (Na+)
channels (VGSCs), and preclinical studies show that these medications reduce tumour …

A plethora of ion channels have been shown to be involved systemically in the
pathophysiology of cancer and ion channel blockers can produce anti-metastatic effects …

Ion channels are transmembrane structures that allow the passage of ions across cell
membranes such as the plasma membrane or the membranes of various organelles like the …

The prevalence of non-small cell lung cancer (NSCLC), particularly in the Eastern Region of
Saudi Arabia, is concerning and highlights the need for novel treatments, despite recent …

Background Breast cancer is the most common malignant cancer and is the second most
common cause of cancer-related deaths among females worldwide. Thus, it warrants the …