Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Genetic disorders of surfactant dysfunction result in significant morbidity and mortality,
among infants, children, and adults. Available medical interventions are limited, nonspecific …

Disruption of alveolar type 2 cell (AEC2) protein quality control has been implicated in
chronic lung diseases, including pulmonary fibrosis (PF). We previously reported the in vivo …

Interstitial lung disease (ILD) represents a large group of diseases characterized by chronic
inflammation and fibrosis of the lungs, for which therapeutic options are limited. Among …

Lung diseases, including lung cancer, are rising causes of global mortality. Despite novel
imaging technologies and the development of biomarker assays, the detection of lung …

With ever-increasing intensive studies of idiopathic pulmonary fibrosis (IPF), significant
progresses have been made. Endoplasmic reticulum stress (ERS)/unfolded protein reaction …

Pulmonary fibrosis is a disease process associated with significant morbidity and mortality,
with limited therapeutic options owing to an incomplete understanding of the underlying …

The Toll-like receptor (TLR) adaptor protein MyD88 is integral to airway inflammatory
response to microbial-enriched organic dust extract (ODE) exposures. ODE-induced airway …

Abstract Background Surfactant protein C (SP-C) disorder is a major component of
hereditary interstitial lung disease (HILD) among Japanese. The correlation between clinical …

Mesenchymal stromal cells (MSCs) have been proposed as a new therapeutic strategy to
treat congenital and acquired respiratory system diseases. We describe a case report of an …