Natural and targeted circuit reorganization after spinal cord injury
A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …
cord that regulate neurological functions. The consequences are permanent paralysis, loss …
[HTML][HTML] Current principles of motor control, with special reference to vertebrate locomotion
S Grillner, A El Manira - Physiological reviews, 2019 - journals.physiology.org
The vertebrate control of locomotion involves all levels of the nervous system from cortex to
the spinal cord. Here, we aim to cover all main aspects of this complex behavior, from the …
the spinal cord. Here, we aim to cover all main aspects of this complex behavior, from the …
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …
Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis
Cerebral strokes can disrupt descending commands from motor cortical areas to the spinal
cord, which can result in permanent motor deficits of the arm and hand. However, below the …
cord, which can result in permanent motor deficits of the arm and hand. However, below the …
A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease
People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor
deficits that are resistant to currently available therapies. To alleviate these deficits, we …
deficits that are resistant to currently available therapies. To alleviate these deficits, we …
Targeted neurotechnology restores walking in humans with spinal cord injury
FB Wagner, JB Mignardot, CG Le Goff-Mignardot… - Nature, 2018 - nature.com
Spinal cord injury leads to severe locomotor deficits or even complete leg paralysis. Here we
introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control …
introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control …
[HTML][HTML] The neurons that restore walking after paralysis
A spinal cord injury interrupts pathways from the brain and brainstem that project to the
lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural …
lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural …
Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice
Optoelectronic systems can exert precise control over targeted neurons and pathways
throughout the brain in untethered animals, but similar technologies for the spinal cord are …
throughout the brain in untethered animals, but similar technologies for the spinal cord are …
[HTML][HTML] Neuroprosthetics: from sensorimotor to cognitive disorders
Neuroprosthetics is a multidisciplinary field at the interface between neurosciences and
biomedical engineering, which aims at replacing or modulating parts of the nervous system …
biomedical engineering, which aims at replacing or modulating parts of the nervous system …
Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces
D Afanasenkau, D Kalinina, V Lyakhovetskii… - Nature biomedical …, 2020 - nature.com
Neuromuscular interfaces are required to translate bioelectronic technologies for application
in clinical medicine. Here, by leveraging the robotically controlled ink-jet deposition of low …
in clinical medicine. Here, by leveraging the robotically controlled ink-jet deposition of low …