Undenatured type II collagen and its role in improving osteoarthritis
R Xu, J Wu, L Zheng, M Zhao - Ageing Research Reviews, 2023 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease, affecting 32.5 million US adults or 242
million people worldwide. There is no cure for OA. Many animal and clinical trials showed …
million people worldwide. There is no cure for OA. Many animal and clinical trials showed …
Nanomaterial-based reactive oxygen species scavengers for osteoarthritis therapy
S Zhang, L Wang, Y Kang, J Wu, Z Zhang - Acta Biomaterialia, 2023 - Elsevier
Reactive oxygen species (ROS) play distinct but important roles in physiological and
pathophysiological processes. Recent studies on osteoarthritis (OA) have suggested that …
pathophysiological processes. Recent studies on osteoarthritis (OA) have suggested that …
Role of mesenchymal stem cells and their paracrine mediators in macrophage polarization: an approach to reduce inflammation in osteoarthritis
SS Kuppa, HK Kim, JY Kang, SC Lee… - International Journal of …, 2022 - mdpi.com
Osteoarthritis (OA) is a low-grade inflammatory disorder of the joints that causes
deterioration of the cartilage, bone remodeling, formation of osteophytes, meniscal damage …
deterioration of the cartilage, bone remodeling, formation of osteophytes, meniscal damage …
Apoptotic neutrophil membrane-camouflaged liposomes for dually targeting synovial macrophages and fibroblasts to attenuate osteoarthritis
C Deng, Y Chen, X Zhao, L Yu, Y Xiao… - … Applied Materials & …, 2023 - ACS Publications
No current pharmacological approach is capable of simultaneously inhibiting the
symptomatology and structural progression of osteoarthritis. M1 macrophages and activated …
symptomatology and structural progression of osteoarthritis. M1 macrophages and activated …
Paroxetine attenuates chondrocyte pyroptosis and inhibits osteoclast formation by inhibiting NF-κB pathway activation to delay osteoarthritis progression
X Zheng, J Qiu, N Gao, T Jiang, Z Li… - Drug Design …, 2023 - Taylor & Francis
Background Osteoarthritis (OA), a common chronic joint disease, is characterized by
cartilage degeneration and subchondral bone reconstruction. NF-κB signaling pathway …
cartilage degeneration and subchondral bone reconstruction. NF-κB signaling pathway …
[HTML][HTML] CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer
Q Lv, Y Zhang, W Gao, J Wang, Y Hu, H Yang… - Pharmacological …, 2024 - Elsevier
PD-1 blockade therapy has made great breakthroughs in treatment of multiple solid tumors.
However, patients with microsatellite-stable (MSS) colorectal cancer (CRC) respond poorly …
However, patients with microsatellite-stable (MSS) colorectal cancer (CRC) respond poorly …
Pt–Se Hybrid Nanozymes with Potent Catalytic Activities to Scavenge ROS/RONS and Regulate Macrophage Polarization for Osteoarthritis Therapy
H Wei, H Huang, H He, Y Xiao, L Chun, Z Jin, H Li… - Research, 2024 - spj.science.org
The activation of pro-inflammatory M1-type macrophages by overexpression of reactive
oxygen species (ROS) and reactive nitrogen species (RONS) in synovial membranes …
oxygen species (ROS) and reactive nitrogen species (RONS) in synovial membranes …
Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders
L Lu, Y Xiong, Z Lin, X Chu, AC Panayi, Y Hu… - Frontiers in …, 2022 - frontiersin.org
Extensive research has implicated inflammation and oxidative stress in the development of
multiple diseases, such as diabetes, hepatitis, and arthritis. Kinsenoside (KD), a bioactive …
multiple diseases, such as diabetes, hepatitis, and arthritis. Kinsenoside (KD), a bioactive …
Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl− efflux signaling pathway
Z Zhang, S Xie, J Qian, F Gao, W Jin, L Wang… - Journal of Translational …, 2023 - Springer
Background Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely
related to cartilage destruction and could occur at any stage, is an inflammatory arthritis …
related to cartilage destruction and could occur at any stage, is an inflammatory arthritis …
Opsonization Inveigles Macrophages Engulfing CarrierFree Bilirubin/JPH203 Nanoparticles to Suppress Inflammation for Osteoarthritis Therapy
H Huang, S Zheng, J Wu, X Liang, S Li… - Advanced …, 2024 - Wiley Online Library
Osteoarthritis (OA) is a chronic inflammatory disease characterized by cartilage destruction,
synovitis, and osteophyte formation. Diseasemodifying treatments for OA are currently …
synovitis, and osteophyte formation. Diseasemodifying treatments for OA are currently …