Pulmonary hypertension (PH) frequently complicates the course of patients with various
forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic
diseases in neonates, infants, and older children and contributes to significant morbidity and …

The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic
effects in multiple organs including brain, heart, and skeletal muscle by serving as an …

The use of substances and medications with potential cardiovascular effects among those
practicing sports and physical activity has progressively increased in recent years. This is …

Progression of pulmonary hypertension is associated with increased proliferation and
migration of pulmonary vascular smooth muscle cells. PDGF is a potent mitogen and …

Altitude exposure is associated with major changes in cardiovascular function. The initial
cardiovascular response to altitude is characterized by an increase in cardiac output with …

Léon-Velarde, Fabiola, Marco Maggiorini, John T. Reeves, Almaz Aldashev, Ingrid Asmus,
Luciano Bernardi, Ri-Li Ge, Peter Hackett, Toshio Kobayashi, Lorna G. Moore, Dante …

In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has
evolved from a potential anti-angina drug to an on-demand oral treatment for erectile …

Dihydropyridine calcium channel blockers (CCB) are typically used agents in the clinical
management of hypertension. Yet, they have also been utilized in the treatment of various …