The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

The four Janus kinase (JAK) proteins and seven signal transducer and activator of
transcription (STAT) transcription factors mediate intracellular signal transduction …

Cytokines are involved in intestinal homeostasis and pathological processes associated
with inflammatory bowel disease (IBD). The biological effects of cytokines, including several …

The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …

We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the
transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I …

The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non‐
receptor protein tyrosine kinases. They are involved in cell growth, survival, development …

▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …

▪ Abstract Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation
of immune responses. Its effects depend upon binding to and signaling through a receptor …

Abstract Interleukin-4 (IL-4) stimulation of cells leads to the activation of multiple signaling
pathways, one of which involves Stat6. We have generated Stat6-deficient mice by gene …

GLUCOCORTICOID hormones are important for vital functions and act to modulate
inflammatory and immune responses1, 2. Yet, in contrast to other hormonal systems, no …