Schizophrenia: from neurochemistry to circuits, symptoms and treatments

OD Howes, BR Bukala, K Beck - Nature Reviews Neurology, 2024 - nature.com
Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …

Rethinking the first episode of schizophrenia: identifying convergent mechanisms during development and moving toward prediction

JK Forsyth, CE Bearden - American Journal of Psychiatry, 2023 - Am Psychiatric Assoc
The neurodevelopmental hypothesis of schizophrenia has long suggested that the cardinal
psychotic symptoms that have traditionally defined the disorder, and which most commonly …

Assessing NH300094, a novel dopamine and serotonin receptor modulator with cognitive enhancement property for treating schizophrenia

Z Feng, Z Hu, L Li, M Yu, Y Zhang, P Jing… - Frontiers in …, 2024 - frontiersin.org
Background: Schizophrenia is a serious psychiatric disorder that significantly affects the
quality of life of patients. The objective of this study is to discover a novel antipsychotic …

Inhibition of reactive oxygen species production accompanying alternatively activated microglia by risperidone in a mouse ketamine model of schizophrenia

R Fujikawa, J Yamada, S Maeda… - Journal of …, 2024 - Wiley Online Library
Recent studies have highlighted the potential involvement of reactive oxygen species (ROS)
and microglia, a major source of ROS, in the pathophysiology of schizophrenia. In our study …

A lifetime of mental health treatments for people with schizophrenia: update and narrative review

LE DeLisi - Current Opinion in Psychiatry, 2024 - journals.lww.com
A focus should be made by clinicians to personalize treatment plans for each patient who
has the possibility of being diagnosed with a primary psychosis and the plan should be to …

Diffusion Magnetic Resonance Imaging for Treatment Response Prediction in Schizophrenia Spectrum Disorders: A Systematic Review

M Parsaei, A Sheipouri, P Partovifar… - Psychiatry Research …, 2024 - Elsevier
A substantial portion of schizophrenia spectrum disorder (SSD) patients exhibit resistance to
antipsychotic treatments, emphasizing the need for reliable treatment response biomarkers …

Schizophrenia: Disability, Clinical Insights, and Management

A Rizvi, SR Safwi, MA Usmani - The Palgrave Encyclopedia of Disability, 2024 - Springer
Schizophrenia is a complex psychiatric disorder characterized by a wide range of symptoms
including hallucinations, delusions, disorganized speech, and cognitive impairments. It is …

Antipsychotics: beyond dopamine

M Greener - Prescriber, 2024 - Wiley Online Library
People with schizophrenia often experience considerable difficulties in daily life because of
a wide constellation of symptoms associated with the condition. This article examines the …

Los receptores muscarínicos como potencial objetivo terapéutico en la esquizofrenia

JEL Villa - Revista eNeurobiología, 2024 - eneurobiologia.uv.mx
La esquizofrenia es una enfermedad mental crónica caracterizada por tres conjuntos de
síntomas: positivos, negativos y cognitivos. Aunque los primeros han logrado abordarse con …

Dinâmica relacional familiar no pós-alta hospitalar do doente mental grave: Intervenção do EEESMP

ACSM Silva - 2024 - comum.rcaap.pt
A inclusão da família e do doente no projeto terapêutico para a recuperação da pessoa com
Doença Mental Grave assume grande importância, desde o internamento até aos cuidados …