The measurement of spontaneous ongoing pain in rodents is a multiplex issue and a subject
of extensive and longstanding debate. Considering the need to align available rodent …

The human experience of pain is multidimensional and comprises sensory, affective, and
cognitive dimensions. Preclinical assessment of pain has been largely focused on the …

Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment
of neuropathic pain. The analgesia lasts for several months after a single treatment …

Oral cancer patients report sensitivity to spicy foods and liquids. The mechanism responsible
for chemosensitivity induced by oral cancer is not known. We simulate oral cancer-induced …

Painful diabetic neuropathy (PDN) is an intractable complication of diabetes that affects 25%
of patients. PDN is characterized by neuropathic pain and small-fiber degeneration …

The ability of the body to perceive noxious stimuli lies in a heterogeneous group of primary
somatosensory neurons termed nociceptors. The molecular receptors of noxious …

Osteoarthritis (OA) is a chronic condition characterized by pain during joint movement.
Additionally, patients with advanced disease experience pain at rest (ie, ongoing pain) that …

Neuropathic pain (NP) results from injury to or disease of the somatosensory system. It is
estimated that approximately 7% to 10% of the population and 25% to 30% of individuals …

Pain involves an intrinsically dynamic connectome characterized by fluctuating spontaneous
brain activity and continuous neuroplastic changes of relevant circuits. Activity in the …

Partial nerve injury leads to peripheral neuropathic pain. This injury results in conducting/
uninterrupted (also called uninjured) sensory fibres, conducting through the damaged nerve …