Plant biosynthetic gene clusters in the context of metabolic evolution

SJ Smit, BR Lichman - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Plants produce a wide range of structurally and biosynthetically
diverse natural products to interact with their environment. These specialised metabolites …

Subcellular compartmentalization in the biosynthesis and engineering of plant natural produces

L Yao, X Wu, X Jiang, M Shan, Z Zhang, Y Li… - Biotechnology …, 2023 - Elsevier
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …

NextDenovo: an efficient error correction and accurate assembly tool for noisy long reads

J Hu, Z Wang, Z Sun, B Hu, AO Ayoola, F Liang, J Li… - Genome Biology, 2024 - Springer
Long-read sequencing data, particularly those derived from the Oxford Nanopore
sequencing platform, tend to exhibit high error rates. Here, we present NextDenovo, an …

Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family

F Zhang, F Qiu, J Zeng, Z Xu, Y Tang, T Zhao… - Nature …, 2023 - nature.com
Tropane alkaloids (TAs) are widely distributed in the Solanaceae, while some important
medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted …

Emerging mechanistic insights into the regulation of specialized metabolism in plants

LV Méteignier, HW Nützmann, N Papon, A Osbourn… - Nature plants, 2023 - nature.com
Plants biosynthesize a broad range of natural products through specialized and species-
specific metabolic pathways that are fuelled by core metabolism, together forming a …

Subgenome-aware analyses suggest a reticulate allopolyploidization origin in three Papaver genomes

RG Zhang, C Lu, GY Li, J Lv, L Wang, ZX Wang… - Nature …, 2023 - nature.com
Hybridization and polyploidization are important driving forces in angiosperm evolution,
resulting in novel phenotypes capable of prompting ecological diversification and invasion …

Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis

W Sun, Q Yin, H Wan, R Gao, C Xiong, C Xie… - Nature …, 2023 - nature.com
Horse chestnut (Aesculus chinensis) is an important medicinal tree that contains various
bioactive compounds, such as aescin, barrigenol-type triterpenoid saponins (BAT), and …

Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia

J Hu, S Qiu, F Wang, Q Li, CL Xiang, P Di, Z Wu… - Nature …, 2023 - nature.com
Abstract The genus Salvia L.(Lamiaceae) comprises myriad distinct medicinal herbs, with
terpenoids as one of their major active chemical groups. Abietane-type diterpenoids (ATDs) …

Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory

AE Bryson, ER Lanier, KH Lau, JP Hamilton… - Nature …, 2023 - nature.com
The spatial organization of genes within plant genomes can drive evolution of specialized
metabolic pathways. Terpenoids are important specialized metabolites in plants with diverse …

TCMPG: an integrative database for traditional Chinese medicine plant genomes

F Meng, Q Tang, T Chu, X Li, Y Lin, X Song… - Horticulture …, 2022 - academic.oup.com
Because of their great therapeutic and economic value, medicinal plants have attracted
increasing scientific attention. With the rapid development of high-throughput sequencing …