[PDF][PDF] Association between liver‐specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease

LA Adams, SW White, JA Marsh, SJ Lye… - …, 2013 - Wiley Online Library
Genetic factors account for a significant proportion of the phenotypic variance of
nonalcoholic fatty liver disease (NAFLD); however, very few predisposing genes have been …

Development of hepatocellular carcinoma in Japanese patients with biopsy‐proven non‐alcoholic fatty liver disease: association between PNPLA3 genotype and …

Y Seko, Y Sumida, S Tanaka, K Mori… - Hepatology …, 2017 - Wiley Online Library
Aim Some patients with non‐alcoholic fatty liver disease (NAFLD) develop hepatocellular
carcinoma (HCC). Patatin‐like phospholipase domain containing 3 (PNPLA3) rs738409 …

[HTML][HTML] A “systems medicine” approach to the study of non-alcoholic fatty liver disease

S Petta, L Valenti, E Bugianesi, G Targher… - Digestive and Liver …, 2016 - Elsevier
The prevalence of fatty liver (steatosis) in the general population is rapidly increasing
worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the …

[PDF][PDF] Association of γ‐glutamyl transferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV)

JE Everhart, EC Wright - Hepatology, 2013 - Wiley Online Library
Increased γ‐glutamyl transferase (GGT) activity is associated with liver injury and with
mortality in the general population. Less is known about its association with chronic hepatitis …

[HTML][HTML] PNPLA3 gene and kidney disease

A Mantovani, C Zusi - Exploration of medicine, 2020 - explorationpub.com
Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present,
CKD is described as a change of kidney structure and/or function and it is classified in …

Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction

MM Hassan, A Kaseb, CJ Etzel… - Molecular …, 2013 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic with high prevalence in
Western countries. Genome‐wide association studies had reported that a variation in the …

Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due to PNPLA3 Sequence Variant

RM Mancina, N Matikainen, C Maglio… - The Journal of …, 2015 - academic.oup.com
Context: Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic disease
characterized by increased hepatic fat, due to an imbalance between synthesis and removal …

Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration

R Zampino, MA Pisaturo, G Cirillo, A Marrone… - Annals of …, 2015 - medigraphic.com
Hepatocellular carcinoma (HCC) is a development of severe liver disease frequently due to
HBV and/or HCV infection. The aim of this retrospective study was to evaluate the …

Cardiovascular diseases and HCV infection: a simple association or more?

S Petta, FS Macaluso, A Craxì - Gut, 2014 - gut.bmj.com
HCV infection, metabolic disorders and cardiovascular alterations, considered alone or in
combination, are common conditions in a large proportion of the general population …

The rs738409 (I148M) variant of the PNPLA3 gene and cirrhosis: a meta-analysis

JH Shen, YL Li, D Li, NN Wang, L Jing… - Journal of lipid …, 2015 - ASBMB
The human patatin-like phospholipase domain-containing-3 (PNPLA3) gene rs738409 C> G
polymorphism is associated with several types of liver disease. The aim of this meta-analysis …