[PDF][PDF] Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients

M Milano, A Aghemo, RM Mancina, J Fischer… - …, 2015 - Wiley Online Library
Steatosis and inherited host factors influence liver damage progression in chronic hepatitis
C (CHC). The transmembrane 6 superfamily member 2 (TM6SF2) gene E167K variant …

An update on the validity of irisin assays and the link between irisin and hepatic metabolism

SA Polyzos, CS Mantzoros - Metabolism, 2015 - Elsevier
Common diseases (including obesity, type 2 diabetes mellitus [T2DM], cardiovascular
disease and nonalcoholic fatty liver disease [NAFLD]) are complex traits resulting from …

PNPLA3 (rs738409 C> G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis

E Trepo, E Guyot, N Ganne-Carrie, D Degre… - Hepatology, 2012 - journals.lww.com
In their study, Iavarone et al. 1 found a prolonged time to progression (TTP) in comparison
with the Sorafenib HCC Assessment Randomized Protocol study, and they speculated that it …

Insights from genome-wide association analyses of nonalcoholic fatty liver disease

B Kahali, B Halligan, EK Speliotes - Seminars in liver disease, 2015 - thieme-connect.com
Nonalcoholic fatty liver disease (NAFLD) is caused by hepatic steatosis, which can progress
to nonalcoholic steatohepatitis, fibrosis/cirrhosis, and hepatocellular carcinoma in the …

[PDF][PDF] Patatin‐like phospholipase domain‐containing 3 I148M affects liver steatosis in patients with chronic hepatitis B

M Viganò, L Valenti, P Lampertico, F Facchetti… - …, 2013 - Wiley Online Library
Steatosis is a common histopathological feature of chronic hepatitis B (CHB) and has been
associated with severity of liver disease. Recently, the rs738409 I148M patatin‐like …

Genome‐Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy

Y Liu, CA Fernandez, C Smith, W Yang… - Clinical …, 2017 - Wiley Online Library
Remission induction therapy for acute lymphoblastic leukemia (ALL) includes medications
that may cause hepatotoxicity, including asparaginase. We used a genome‐wide …

[HTML][HTML] PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease

L Valenti, P Dongiovanni, SG Corradini… - Digestive and Liver …, 2013 - Elsevier
Hepatocellular carcinoma (HCC) is highly associated with chronic liver disease. The
rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3 …

TM 6 SF 2 E167K variant is associated with severe steatosis in chronic hepatitis C, regardless of PNPLA 3 polymorphism

N Coppola, Z Rosa, G Cirillo, M Stanzione… - Liver …, 2015 - Wiley Online Library
Background & Aims A common non‐synonymous polymorphism, E167K, in transmembrane
six superfamily member 2 (TM 6 SF 2) gene has been recently associated with an increased …

Metabolic alterations and chronic hepatitis C: treatment strategies

LE Adinolfi, L Restivo, R Zampino… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Chronic hepatitis C (HCV) infection is considered a metabolic disease. It is
associated with a specific metabolic syndrome, HCV-associated dysmetabolic syndrome …

[PDF][PDF] Diarrhea predicts a positive response to sorafenib in patients with advanced hepatocellular carcinoma

D Bettinger, M Schultheiβ, E Knüppel, R Thimme… - …, 2012 - Wiley Online Library
I read with interest the article regarding the role of imaging techniques in the treatment of
hepatocellular carcinoma (HCC) by Bruix et al. published in HEPATOLOGY. 1 In this special …