PNPLA3 in end‐stage liver disease: Alcohol consumption, hepatocellular carcinoma development, and transplantation‐free survival
K Friedrich, A Wannhoff, S Kattner… - Journal of …, 2014 - Wiley Online Library
Abstract Background and Aims The rs738409 variant (I 148 M) of the patatin‐like
phospholipase domain‐containing protein 3 (PNPLA3) gene is associated with several liver …
phospholipase domain‐containing protein 3 (PNPLA3) gene is associated with several liver …
PNPLA3 I148M (rs738409) genetic variant and age at onset of at‐risk alcohol consumption are independent risk factors for alcoholic cirrhosis
MA Burza, A Molinaro, ML Attilia, C Rotondo… - Liver …, 2014 - Wiley Online Library
Abstract Background & Aims Environmental and genetic factors contribute to alcoholic
cirrhosis onset. In particular, age at exposure to liver stressors has been shown to be …
cirrhosis onset. In particular, age at exposure to liver stressors has been shown to be …
A polygenetic risk score combined with environmental factors better predict susceptibility to hepatocellular carcinoma in Chinese population
Aims This study aimed to investigate environmental factors and genetic variant loci
associated with hepatocellular carcinoma (HCC) in Chinese population and construct a …
associated with hepatocellular carcinoma (HCC) in Chinese population and construct a …
Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study
P Trunečka, I Míková, D Dlouhá, JA Hubáček… - Digestive and liver …, 2018 - Elsevier
Background & aims The rs738409 c. 444C> G (p. I148M) polymorphism in PNPLA3 is a
major factor predisposing to non-alcoholic fatty liver disease. The aim of the study was to …
major factor predisposing to non-alcoholic fatty liver disease. The aim of the study was to …
Genetic and epigenetic profile of patients with alcoholic liver disease
L Boccuto, L Abenavoli - Annals of Hepatology, 2017 - medigraphic.com
Alcoholic liver disease (ALD) is a definition encompassing a spectrum of disorders ranging
from simple steatosis to cirrhosis and hepatocellular carcinoma. Excessive alcohol …
from simple steatosis to cirrhosis and hepatocellular carcinoma. Excessive alcohol …
[HTML][HTML] New insights into genetic predisposition and novel therapeutic targets for nonalcoholic fatty liver disease
M Barbara, A Scott, N Alkhouri - Hepatobiliary surgery and nutrition, 2018 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in
the United States affecting 80–100 million Americans. NAFLD encompasses a spectrum of …
the United States affecting 80–100 million Americans. NAFLD encompasses a spectrum of …
Host genetic variants influencing the clinical course of hepatitis C virus infection
K Matsuura, Y Tanaka - Journal of medical virology, 2016 - Wiley Online Library
The clinical course of hepatitis C virus (HCV) infection greatly differs in individuals. Various
viral, host, and environmental factors influence the natural history of HCV infection. Recent …
viral, host, and environmental factors influence the natural history of HCV infection. Recent …
[HTML][HTML] Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases
H Xiang, Z Wu, J Wang, T Wu - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
The human patatin-like phospholipase domain-containing 3 gene (PNPLA3) is highly
expressed in liver and adipose tissue and encodes a transmembrane polypeptide chain …
expressed in liver and adipose tissue and encodes a transmembrane polypeptide chain …
[HTML][HTML] Investigation of PNPLA3 and IL28B genotypes on diabetes and obesity after liver transplantation: insight into mechanisms of disease
KD Watt, R Dierkhising, C Fan, JK Heimbach… - American Journal of …, 2013 - Elsevier
To identify genetic risks for obesity and diabetes postliver transplantation (LT), LT recipients
underwent genotyping for IL28B rs12979860 (n= 295) and PNPLA3 rs738409 (n= 205) …
underwent genotyping for IL28B rs12979860 (n= 295) and PNPLA3 rs738409 (n= 205) …
Metabolic dysfunction outperforms ultrasonographic steatosis to stratify hepatocellular carcinoma risk in patients with advanced hepatitis C cured with direct‐acting …
S Pelusi, C Bianco, M Colombo, G Cologni… - Liver …, 2023 - Wiley Online Library
Abstract Background and Aims Metabolic dysfunction (MD)‐associated fatty liver disease
has been proposed to identify individuals at risk of liver events irrespectively of the …
has been proposed to identify individuals at risk of liver events irrespectively of the …