Early adversity and critical periods: neurodevelopmental consequences of violating the expectable environment
CA Nelson, LJ Gabard-Durnam - Trends in neurosciences, 2020 - cell.com
It is now widely recognized that children exposed to adverse life events in the first years of
life are at increased risk for a variety of neural, behavioral, and psychological sequelae. As …
life are at increased risk for a variety of neural, behavioral, and psychological sequelae. As …
The role of GABAergic signalling in neurodevelopmental disorders
GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …
exciting new discoveries provides compelling evidence that disruptions in a number of key …
Balancing plasticity/stability across brain development
AE Takesian, TK Hensch - Progress in brain research, 2013 - Elsevier
The potency of the environment to shape brain function changes dramatically across the
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …
[HTML][HTML] Development and plasticity of the primary visual cortex
JS Espinosa, MP Stryker - Neuron, 2012 - cell.com
Hubel and Wiesel began the modern study of development and plasticity of primary visual
cortex (V1), discovering response properties of cortical neurons that distinguished them from …
cortex (V1), discovering response properties of cortical neurons that distinguished them from …
Critical period plasticity in local cortical circuits
TK Hensch - Nature Reviews Neuroscience, 2005 - nature.com
Neuronal circuits in the brain are shaped by experience during'critical periods' in early
postnatal life. In the primary visual cortex, this activity-dependent development is triggered …
postnatal life. In the primary visual cortex, this activity-dependent development is triggered …
GABA receptors in brain development, function, and injury
C Wu, D Sun - Metabolic brain disease, 2015 - Springer
This review presents a brief overview of the γ-aminobutyric acid (GABA) system in the
developing and mature central nervous system (CNS) and its potential connections to …
developing and mature central nervous system (CNS) and its potential connections to …
[HTML][HTML] Neuronal dynamics and neuropsychiatric disorders: toward a translational paradigm for dysfunctional large-scale networks
PJ Uhlhaas, W Singer - Neuron, 2012 - cell.com
In recent years, numerous studies have tested the relevance of neural oscillations in
neuropsychiatric conditions, highlighting the potential role of changes in temporal …
neuropsychiatric conditions, highlighting the potential role of changes in temporal …
Critical period regulation
TK Hensch - Annu. Rev. Neurosci., 2004 - annualreviews.org
▪ Abstract Neuronal circuits are shaped by experience during critical periods of early
postnatal life. The ability to control the timing, duration, and closure of these heightened …
postnatal life. The ability to control the timing, duration, and closure of these heightened …
Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex
M Beurdeley, J Spatazza, HHC Lee… - Journal of …, 2012 - Soc Neuroscience
Specific transfer of (orthodenticle homeobox 2) Otx2 homeoprotein into GABAergic
interneurons expressing parvalbumin (PV) is necessary and sufficient to open, then close, a …
interneurons expressing parvalbumin (PV) is necessary and sufficient to open, then close, a …
[HTML][HTML] Sensory integration in mouse insular cortex reflects GABA circuit maturation
Insular cortex (IC) contributes to a variety of complex brain functions, such as
communication, social behavior, and self-awareness through the integration of sensory …
communication, social behavior, and self-awareness through the integration of sensory …