5-Fluorouracil: mechanisms of resistance and reversal strategies
N Zhang, Y Yin, SJ Xu, WS Chen - Molecules, 2008 - mdpi.com
The purpose of this work is to review the published studies on the mechanisms of action and
resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of …
resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of …
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
PR Turner, K O'Connor, WP Tate, WC Abraham - Progress in neurobiology, 2003 - Elsevier
Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease
Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of
Alzheimer's disease (AD) and is considered to result from neurodegeneration. T-tau levels …
Alzheimer's disease (AD) and is considered to result from neurodegeneration. T-tau levels …
Alzheimer's disease: the two-hit hypothesis
There are many lines of evidence showing that oxidative stress and aberrant mitogenic
changes have important roles in the pathogenesis of Alzheimer's disease (AD). However …
changes have important roles in the pathogenesis of Alzheimer's disease (AD). However …
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—relevance for Alzheimer's disease
T Müller, HE Meyer, R Egensperger, K Marcus - Progress in neurobiology, 2008 - Elsevier
Since the discovery of the amyloid precursor protein (APP) in 1987, extensive research has
been conducted analyzing the APP-derived β-amyloid (Aβ) which is found in massive …
been conducted analyzing the APP-derived β-amyloid (Aβ) which is found in massive …
The amyloid‐β precursor protein: integrating structure with biological function
C Reinhard, SS Hébert, B De Strooper - The EMBO journal, 2005 - embopress.org
Proteolytic processing of the amyloid‐β precursor protein (APP) generates the Aβ amyloid
peptide of Alzheimer's disease. The biological function of APP itself remains, however …
peptide of Alzheimer's disease. The biological function of APP itself remains, however …
Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer's disease
H Bukhari, A Glotzbach, K Kolbe, G Leonhardt… - Progress in …, 2017 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease with tens of
millions of people affected worldwide. The pathogenesis is still poorly understood and …
millions of people affected worldwide. The pathogenesis is still poorly understood and …
The FE65 proteins and Alzheimer's disease
DM McLoughlin, CCJ Miller - Journal of neuroscience research, 2008 - Wiley Online Library
Abstract The FE65s (FE65, FE65L1, and FE65L2) are a family of multidomain adaptor
proteins that form multiprotein complexes with a range of functions. FE65 is brain‐enriched …
proteins that form multiprotein complexes with a range of functions. FE65 is brain‐enriched …
SUMOylation-mediated PSME3-20S proteasomal degradation of transcription factor CP2c is crucial for cell cycle progression
SH Son, MY Kim, YS Lim, HC Jin, JH Shin, JK Yi… - Science …, 2023 - science.org
Transcription factor CP2c (also known as TFCP2, α-CP2, LSF, and LBP-1c) is involved in
diverse ubiquitous and tissue/stage-specific cellular processes and in human malignancies …
diverse ubiquitous and tissue/stage-specific cellular processes and in human malignancies …
Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis
CJ Carter - Neurochemistry international, 2007 - Elsevier
Polymorphic genes associated with Alzheimer's disease (see) delineate a clearly defined
pathway related to cerebral and peripheral cholesterol and lipoprotein homoeostasis. They …
pathway related to cerebral and peripheral cholesterol and lipoprotein homoeostasis. They …