A BMI in the normal range associates with a decreased risk of cardiometabolic disease and
all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared …

Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …

Background The overall incidence of colorectal cancer is decreasing in many high-income
countries, yet analyses in the USA and other high-income countries such as Australia …

Physical activity has been associated with lower risks of breast and colorectal cancer in
epidemiological studies; however, it is unknown if these associations are causal or …

Background Diabetes and high body-mass index (BMI) are associated with increased risk of
several cancers, and are increasing in prevalence in most countries. We estimated the …

Elevated circulating insulin levels are frequently observed in the setting of obesity and early
type 2 diabetes, as a result of insensitivity of metabolic tissues to the effects of insulin. Higher …

The study aimed to perform a systematic review and meta-analysis of the evidence for the
prevention of future cancers following bariatric surgery. A systematic literature search of the …

Objectives: The metabolic dysfunction driven by obesity, including hyperglycemia and
dyslipidemia, increases risk for developing at least 13 cancer types. The concept of …

Aims The hypothesis of 'metabolically healthy obesity'implies that, in the absence of
metabolic dysfunction, individuals with excess adiposity are not at greater cardiovascular …

Fluorouracil (5-FU) is the first-line chemotherapy drug for colorectal cancer but most of the
patients get resistant to the drug on a longer course of treatment. After the successful use of …