The role of exosomes in CNS inflammation and their involvement in multiple sclerosis

I Selmaj, MP Mycko, CS Raine, KW Selmaj - Journal of neuroimmunology, 2017 - Elsevier
Multiple sclerosis (MS) is a putative autoimmune disease of the central nervous system
(CNS) in which autoreactive immune cells recognizing myelin antigens lead to …

Targeted delivery platforms for the treatment of multiple sclerosis

Z Jan, S Mollazadeh, K Abnous… - Molecular …, 2022 - ACS Publications
Multiple sclerosis (MS) is a neurodegenerative condition of the central nervous system
(CNS) that presents with varying levels of disability in patients, displaying the significance of …

Teriflunomide for oral therapy in multiple sclerosis

A Papadopoulou, L Kappos… - Expert review of clinical …, 2012 - Taylor & Francis
Teriflunomide, the active metabolite of an approved antirheumatic drug, is an emerging oral
therapy for multiple sclerosis (MS). Next to the inhibition of pyrimidine biosynthesis and …

JAK2/STAT3 pathway inhibition by AG490 ameliorates experimental autoimmune encephalomyelitis via regulation of Th17 cells and autophagy

Y Xue, L Zhang, L Chu, Z Song, B Zhang, X Su, W Liu… - Neuroscience, 2024 - Elsevier
Multiple sclerosis (MS) is an autoimmune inflammatory condition affecting the central
nervous system, and experimental autoimmune encephalomyelitis (EAE) animal models …

A Mushroom Extract Piwep from Phellinus igniarius Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Immune Cell Infiltration in the Spinal Cord

L Li, G Wu, BY Choi, BG Jang, JH Kim… - BioMed Research …, 2014 - Wiley Online Library
The present study aimed to evaluate the therapeutic potential of a mushroom extract from
Phellinus igniarius in an animal model of multiple sclerosis. The medicinal mushroom …

Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers

V Pravica, D Popadic, E Savic, M Markovic… - Immunologic …, 2012 - Springer
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative
disease of the central nervous system characterized by unpredictable and variable clinical …

Aberrant expression of the apoptosis-related proteins BAK and MCL1 in T cells in multiple sclerosis

I Mandel, T Paperna, A Miller - Journal of neuroimmunology, 2012 - Elsevier
Pathogenic T cells of multiple sclerosis (MS) patients have been suggested to be endowed
with an increased resistance to apoptosis, contributing to their increased survival. We report …

Was gibt es Neues bei der Multiplen Sklerose?

L Klotz, H Wiendl - Aktuelle Neurologie, 2012 - thieme-connect.com
Im Jahr 2011 wurden die Ergebnisse einer Reihe interessanter klinischer Phase II und III
Studien bei Patienten mit schubförmiger Multipler Sklerose (MS) vorgestellt oder publiziert …

IL-23 Receptor Expression and Effects of Signaling on T Cell Encephalitogenicity

AJ Smith - 2011 - rave.ohiolink.edu
Multiple Sclerosis (MS) is an immune mediated disease of the central nervous system
characterized by the destruction of myelin sheaths surrounding nerve axons, and it is the …

The influence of common infections on clinical course and neurodegeneration in an animal model of multiple sclerosis

P Kumar - 2015 - ediss.uni-goettingen.de
The course of Multiple Sclerosis (MS), a chronic autoimmune disease, can be influenced by
systemic infections. The common notion is that bacterial infections worsen disease …