Zebrafish (Danio rerio): A valuable tool for predicting the metabolism of xenobiotics in humans?

C de Souza Anselmo, VF Sardela, VP de Sousa… - … and Physiology Part C …, 2018 - Elsevier
Zebrafish has become a popular model organism in several lines of biological research
sharing physiological, morphological and histological similarities with mammals. In fact …

[HTML][HTML] Polycyclic aromatic hydrocarbons in bone homeostasis

Q Ye, X Xi, D Fan, X Cao, Q Wang, X Wang… - Biomedicine & …, 2022 - Elsevier
Prolonged exposure to polycyclic aromatic hydrocarbons (PAHs) may result in autoimmune
diseases, such as rheumatoid arthritis (RA) and osteoporosis (OP), which are based on an …

[HTML][HTML] Untangling mechanisms of crude oil toxicity: linking gene expression, morphology and PAHs at two developmental stages in a cold-water fish

E Sørhus, CE Donald, D Da Silva, A Thorsen… - Science of the Total …, 2021 - Elsevier
Early life stages of fish are highly sensitive to crude oil exposure and thus, short term
exposures during critical developmental periods could have detrimental consequences for …

Biomarker responses in zebrafish (Danio rerio) following long-term exposure to microplastic-associated chlorpyrifos and benzo (k) fluoranthene

L Hanslik, B Seiwert, S Huppertsberg, TP Knepper… - Aquatic Toxicology, 2022 - Elsevier
Continuously increasing plastic production causes a constant accumulation of microplastic
particles (MPs) in the aquatic environment, especially in industrialized and urbanized areas …

Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity

J Nöth, W Busch, T Tal, C Lai, A Ambekar… - Archives of …, 2024 - Springer
Inhibition of angiogenesis is an important mode of action for the teratogenic effect of
chemicals and drugs. There is a gap in the availability of simple, experimental screening …

Zebrafish early life stages for toxicological screening: insights from molecular and biochemical markers

D Santos, R Vieira, A Luzio, L Félix - Advances in molecular toxicology, 2018 - Elsevier
In developmental toxicity, the evaluation of early biomarkers may be predictive of later
developmental outcomes. Over the last few years, new models have been proposed for …

Evaluation of the uptake, metabolism, and secretion of toxicants by zebrafish larvae

JC Achenbach, JPM Hui, F Berrue… - Toxicological …, 2022 - academic.oup.com
Zebrafish larvae have classically been used as a high-throughput model with which to test
both the bioactivity and toxicity of known and novel compounds, making them a promising …

[HTML][HTML] Developmental toxicity testing of unsubstituted and methylated 4-and 5-ring polycyclic aromatic hydrocarbons using the zebrafish embryotoxicity test

J Fang, S Dong, PJ Boogaard, IMCM Rietjens… - Toxicology In Vitro, 2022 - Elsevier
The present study evaluates the in vitro developmental toxicity of 4-and 5-ring PAHs
including benz [a] anthracene and benzo [a] pyrene and six of their monomethylated …

Dynamic regulation of gene expression and morphogenesis in the zebrafish embryo test after exposure to all-trans retinoic acid

LMM Samrani, JLA Pennings, N Hallmark, R Bars… - Reproductive …, 2023 - Elsevier
The zebrafish embryotoxicity test (ZET) is widely used in developmental toxicology. The
analysis of gene expression regulation in ZET after chemical exposure provides mechanistic …

The emerging contaminant 3, 3′-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish …

MA Roy, KE Sant, OL Venezia, AB Shipman… - Environmental …, 2019 - Elsevier
dichlorobiphenyl (PCB-11) is an emerging PCB congener widely detected in environmental
samples and human serum, but its toxicity potential is poorly understood. We assessed the …