Zebrafish (Danio rerio): A valuable tool for predicting the metabolism of xenobiotics in humans?
C de Souza Anselmo, VF Sardela, VP de Sousa… - … and Physiology Part C …, 2018 - Elsevier
Zebrafish has become a popular model organism in several lines of biological research
sharing physiological, morphological and histological similarities with mammals. In fact …
sharing physiological, morphological and histological similarities with mammals. In fact …
[HTML][HTML] Polycyclic aromatic hydrocarbons in bone homeostasis
Q Ye, X Xi, D Fan, X Cao, Q Wang, X Wang… - Biomedicine & …, 2022 - Elsevier
Prolonged exposure to polycyclic aromatic hydrocarbons (PAHs) may result in autoimmune
diseases, such as rheumatoid arthritis (RA) and osteoporosis (OP), which are based on an …
diseases, such as rheumatoid arthritis (RA) and osteoporosis (OP), which are based on an …
[HTML][HTML] Untangling mechanisms of crude oil toxicity: linking gene expression, morphology and PAHs at two developmental stages in a cold-water fish
E Sørhus, CE Donald, D Da Silva, A Thorsen… - Science of the Total …, 2021 - Elsevier
Early life stages of fish are highly sensitive to crude oil exposure and thus, short term
exposures during critical developmental periods could have detrimental consequences for …
exposures during critical developmental periods could have detrimental consequences for …
Biomarker responses in zebrafish (Danio rerio) following long-term exposure to microplastic-associated chlorpyrifos and benzo (k) fluoranthene
L Hanslik, B Seiwert, S Huppertsberg, TP Knepper… - Aquatic Toxicology, 2022 - Elsevier
Continuously increasing plastic production causes a constant accumulation of microplastic
particles (MPs) in the aquatic environment, especially in industrialized and urbanized areas …
particles (MPs) in the aquatic environment, especially in industrialized and urbanized areas …
Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity
Inhibition of angiogenesis is an important mode of action for the teratogenic effect of
chemicals and drugs. There is a gap in the availability of simple, experimental screening …
chemicals and drugs. There is a gap in the availability of simple, experimental screening …
Zebrafish early life stages for toxicological screening: insights from molecular and biochemical markers
In developmental toxicity, the evaluation of early biomarkers may be predictive of later
developmental outcomes. Over the last few years, new models have been proposed for …
developmental outcomes. Over the last few years, new models have been proposed for …
Evaluation of the uptake, metabolism, and secretion of toxicants by zebrafish larvae
JC Achenbach, JPM Hui, F Berrue… - Toxicological …, 2022 - academic.oup.com
Zebrafish larvae have classically been used as a high-throughput model with which to test
both the bioactivity and toxicity of known and novel compounds, making them a promising …
both the bioactivity and toxicity of known and novel compounds, making them a promising …
[HTML][HTML] Developmental toxicity testing of unsubstituted and methylated 4-and 5-ring polycyclic aromatic hydrocarbons using the zebrafish embryotoxicity test
J Fang, S Dong, PJ Boogaard, IMCM Rietjens… - Toxicology In Vitro, 2022 - Elsevier
The present study evaluates the in vitro developmental toxicity of 4-and 5-ring PAHs
including benz [a] anthracene and benzo [a] pyrene and six of their monomethylated …
including benz [a] anthracene and benzo [a] pyrene and six of their monomethylated …
Dynamic regulation of gene expression and morphogenesis in the zebrafish embryo test after exposure to all-trans retinoic acid
LMM Samrani, JLA Pennings, N Hallmark, R Bars… - Reproductive …, 2023 - Elsevier
The zebrafish embryotoxicity test (ZET) is widely used in developmental toxicology. The
analysis of gene expression regulation in ZET after chemical exposure provides mechanistic …
analysis of gene expression regulation in ZET after chemical exposure provides mechanistic …
The emerging contaminant 3, 3′-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish …
MA Roy, KE Sant, OL Venezia, AB Shipman… - Environmental …, 2019 - Elsevier
dichlorobiphenyl (PCB-11) is an emerging PCB congener widely detected in environmental
samples and human serum, but its toxicity potential is poorly understood. We assessed the …
samples and human serum, but its toxicity potential is poorly understood. We assessed the …