Revolutionizing viral disease treatment: Phase separation and lysosome/exosome targeting as new areas and new paradigms for antiviral drug research
S Du, X Hu, X Liu, P Zhan - Drug Discovery Today, 2024 - Elsevier
With the advancement of globalization, our world is becoming increasingly interconnected.
However, this interconnection means that once an infectious disease emerges, it can rapidly …
However, this interconnection means that once an infectious disease emerges, it can rapidly …
[HTML][HTML] Host mitochondria: more than an organelle in SARS-CoV-2 infection
S Shoraka, AE Samarasinghe, A Ghaemi… - Frontiers in Cellular …, 2023 - frontiersin.org
Since December 2019, the world has been facing viral pandemic called COVID-19
(Coronavirus disease 2019) caused by a new beta-coronavirus named severe acute …
(Coronavirus disease 2019) caused by a new beta-coronavirus named severe acute …
[HTML][HTML] Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X
X Zhang, L Han, J Hou, H Yang, H Xu, G Li, Q Shu… - Cell Reports, 2024 - cell.com
Summary Cyclic GMP-AMP synthase (cGAS) undergoes liquid-liquid phase separation
(LLPS) to trigger downstream signaling upon double-stranded DNA (dsDNA) stimulation …
(LLPS) to trigger downstream signaling upon double-stranded DNA (dsDNA) stimulation …
Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation
Y Zheng, H Yang, X Zhang, C Gao - Biochimica et Biophysica Acta (BBA) …, 2023 - Elsevier
A global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion
of the human population. Antiviral innate immunity is critical for controlling and eliminating …
of the human population. Antiviral innate immunity is critical for controlling and eliminating …
[HTML][HTML] Intracellular Degradation of SARS-CoV-2 N-Protein Caused by Modular Nanotransporters Containing Anti-N-Protein Monobody and a Sequence That …
YV Khramtsov, AV Ulasov, TN Lupanova… - Pharmaceutics, 2023 - mdpi.com
The proper viral assembly relies on both nucleic acids and structural viral proteins. Thus a
biologically active agent that provides the degradation of one of these key proteins and/or …
biologically active agent that provides the degradation of one of these key proteins and/or …
A Tiny Viral Protein, SARS-CoV-2-ORF7b: Functional Molecular Mechanisms
G Mansueto, G Fusco, G Colonna - Biomolecules, 2024 - mdpi.com
This study presents the interaction with the human host metabolism of SARS-CoV-2 ORF7b
protein (43 aa), using a protein–protein interaction network analysis. After pruning, we …
protein (43 aa), using a protein–protein interaction network analysis. After pruning, we …
[HTML][HTML] Regulation of cellular senescence by innate immunity
J Hou, Y Zheng, C Gao - Biophysics Reports, 2023 - ncbi.nlm.nih.gov
During the COVID-19 pandemic, the interplay between the processes of immunity and
senescence is drawing more and more intensive attention. SARS-CoV-2 infection induces …
senescence is drawing more and more intensive attention. SARS-CoV-2 infection induces …