Phenomapping in heart failure with preserved ejection fraction: insights, limitations, and future directions

AE Peters, J Tromp, SJ Shah, CSP Lam… - Cardiovascular …, 2022 - academic.oup.com
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous entity with
complex pathophysiology and manifestations. Phenomapping is the process of applying …

Endocrine functions of the heart: from bench to bedside

M Volpe, G Gallo, S Rubattu - European Heart Journal, 2023 - academic.oup.com
Heart has a recognized endocrine function as it produces several biologically active
substances with hormonal properties. Among these hormones, the natriuretic peptide (NP) …

Natriuretic peptides: it is time for guided therapeutic strategies based on their molecular mechanisms

G Gallo, S Rubattu, C Autore, M Volpe - International Journal of Molecular …, 2023 - mdpi.com
Natriuretic peptides (NPs) are the principal expression products of the endocrine function of
the heart. They exert several beneficial effects, mostly mediated through guanylate cyclase …

[HTML][HTML] The year in cardiovascular medicine 2021: heart failure and cardiomyopathies

J Bauersachs, RA de Boer, JA Lindenfeld… - Cardiologia …, 2022 - hrcak.srce.hr
Sažetak In the year 2021, the universal definition and classification of heart failure (HF) was
published that defines HF as a clinical syndrome with symptoms and/or signs caused by a …

Sacubitril/valsartan as a therapeutic tool across the range of heart failure phenotypes and ejection fraction spectrum

G Gallo, M Volpe, A Battistoni, D Russo, G Tocci… - Frontiers in …, 2021 - frontiersin.org
Heart failure (HF) is a complex syndrome caused by a variety of structural or functional
cardiac abnormalities as a consequence of several involved pathophysiological pathways …

Effect of sacubitril/valsartan combined with dapagliflozin on long-term cardiac mortality in heart failure with reduced ejection fraction

U Karabulut, K Keskin, D Karabulut, E Yiğit… - Angiology, 2022 - journals.sagepub.com
The angiotensin receptor–neprilysin inhibitor (ARNI) sacubitril/valsartan and sodium-
glucose cotransporter-2 (SGLT-2) inhibitor dapagliflozin have been shown to reduce …

Real-world comparative effectiveness of ARNI versus ACEi/ARB in HF with reduced or mildly reduced ejection fraction

M Fu, A Pivodic, O Käck, M Costa-Scharplatz… - Clinical Research in …, 2023 - Springer
Aims Sacubitril/valsartan is a first-in-class angiotensin receptor–neprilysin inhibitor (ARNI)
with a class-1 guideline recommendation. We assessed the real-world effectiveness of ARNI …

The effect of sacubitril/valsartan treatment on cardiac and renal functions of a patient with cardiorenal syndrome type 4 and Stage 5 ckd after more than three years of …

S Cheng, T Zhou, L Yu, Y Chen, Z Zhang… - Frontiers in …, 2022 - frontiersin.org
It is difficult to treat cardiorenal syndrome (CRS) in clinical practice, which is the common
reason for the death of patients. This report aimed to describe the effects of …

Heart failure with preserved ejection fraction: key stumbling blocks for experimental drugs in clinical trials

A Lloji, J Sreenivasan, J Novograd… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Heart failure with preserved ejection fraction (HFpEF) is a disease with a high
prevalence. Accounting for more than 50% of all heart failure cases, it carries a significant …

Sacubitril/valsartan in heart failure and beyond—from molecular mechanisms to clinical relevance

M Nikolic, I Srejovic, J Jovic, J Sretenovic, J Jeremic… - 2022 - scidar.kg.ac.rs
As the ultimate pathophysiological event, heart failure (HF) may arise from various
cardiovascular (CV) conditions, including sustained pressure/volume overload of the left …