Atherosclerotic cardiovascular disease (CVD) is a major health problem in the United States
and around the world. Evidence accumulated over decades convincingly demonstrates that …

Background The CYP11B2 gene (CYP11B2) encoding aldosterone synthase has been
associated with essential hypertension and some, but not all, studies have reported that the …

PURPOSE: Frailty, which has been conceptualized as a state of decreased physiologic
reserve contributing to functional decline, has a prevalence among older African Americans …

Objectives: We sought to evaluate the effect of the aldosterone synthase promoter
polymorphism on heart failure outcomes for subjects in the African American Heart Failure …

Salt-sensitive hypertension is a complex disease associated with genetic factors. This study
aimed to identify the association between 29 candidate single-nucleotide polymorphisms …

Stroke is a complex disease caused by combination of multiple risk factors. Recent findings
have suggested that stroke has a significant genetic component. Various types of genetic …

ABSTRACT Background and Objectives: Essential hypertension is a complex progressive
cardiovascular disorder. Renin–angiotensin aldosterone system (RAAS) plays a major role …

We analyzed the possible association between aldosterone synthase (CYP11B2) T-344C
polymorphism, which is associated with increased aldosterone activity, and the prevalence …

Two clinical trials, the Randomized ALdosterone Evaluation Study (RALES) and the
EPlerenone HEart failure and SUrvival Study (EPHESUS), have recently shown that …

Because of its comparatively recent evolution, Homo sapiens exhibit relatively little within-
species genomic diversity. However, because of genome size, a proportionately small …