The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …

Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …

Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex
systems. However, a comprehensive single-cell atlas has not been achieved for humans …

One of the most fundamental questions in biology is what types of cells form different tissues
and organs in a functionally coordinated fashion. Larger-scale single-cell sequencing and …

Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …

Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

Spermatogenesis generates mature male gametes and is critical for the proper transmission
of genetic information between generations. However, the developmental landscapes of …

The placenta is crucial for a successful pregnancy and the health of both the fetus and the
pregnant woman. However, how the human trophoblast lineage is regulated, including the …

Aging men display reduced reproductive health; however, testis aging is poorly understood
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …