Background Routine use of whole‐cell pertussis (wP) vaccines was suspended in some
countries in the 1970s and 1980s because of concerns about adverse effects. Following this …

Objective: To assess the efficacy and safety of whole-cell and acellular pertussis vaccines
administered to children singly or within diphtheria, tetanus and pertussis (DTP) vaccines …

Many countries continue to experience pertussis epidemics despite widespread vaccination.
Waning protection after booster vaccination has highlighted the need for a better …

The effect of detoxification of pertussis toxin (PT) for vaccine usage by either genetic
manipulation, hydrogen peroxide or formaldehyde treatment on epitope recognition by a …

A massive diphtheria epidemic in Eastern Europe has resulted in increased anxiety that this
disease could spread to other countries. This fear is realistic because there is a gap in the …

Over two decades ago acellular pertussis vaccines (aP) replaced whole cell pertussis
vaccines (wP) in several countries. Since then, a resurgence in pertussis has been …

Pertussis toxin (PT) is one of the major virulence factors of Bordetella pertussis and the
primary component of all pertussis vaccines available to date. Because of its various …

Background. Although inactivated vaccines are recommended for immunocompromized
patients, efficacy and safety of diphtheria and tetanus immunization in renal transplant …

Two recently developed vaccines—one based on synthetic peptide and one based on
recombinant capsid protein—fully protected dogs against heavy experimental canine …

Uropathogenic Escherichia coli is the most common cause of urinary tract infection (UTI).
Cystitis in women is by far the most common UTI; pyelonephritis in both sexes and prostatitis …