[HTML][HTML] Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential
A Kazanets, T Shorstova, K Hilmi, M Marques… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However,
there are a number of universal aberrations common to all cancers, one of these being the …
there are a number of universal aberrations common to all cancers, one of these being the …
DNA methylation biomarkers for noninvasive detection of triple‐negative breast cancer using liquid biopsy
M Manoochehri, N Borhani… - … Journal of Cancer, 2023 - Wiley Online Library
Noninvasive detection of aberrant DNA methylation could provide invaluable biomarkers for
earlier detection of triple‐negative breast cancer (TNBC) which could help clinicians with …
earlier detection of triple‐negative breast cancer (TNBC) which could help clinicians with …
Aberrant WNT/CTNNB1 signaling as a therapeutic target in human breast cancer: weighing the evidence
EH Van Schie, RE Van Amerongen - Frontiers in cell and …, 2020 - frontiersin.org
WNT signaling is crucial for tissue morphogenesis during development in all multicellular
animals. After birth, WNT/CTNNB1 responsive stem cells are responsible for tissue …
animals. After birth, WNT/CTNNB1 responsive stem cells are responsible for tissue …
DNA hypermethylation during tuberculosis dampens host immune responsiveness
AR DiNardo, K Rajapakshe… - The Journal of …, 2020 - Am Soc Clin Investig
Mycobacterium tuberculosis (M. tuberculosis) has coevolved with humans for millennia and
developed multiple mechanisms to evade host immunity. Restoring host immunity in order to …
developed multiple mechanisms to evade host immunity. Restoring host immunity in order to …
Role of aldo‐keto reductase family 1 member B1 (AKR1B1) in the cancer process and its therapeutic potential
R Khayami, SR Hashemi… - Journal of cellular and …, 2020 - Wiley Online Library
The role of aldo‐keto reductase family 1 member B1 (AKR1B1) in cancer is not totally clear
but growing evidence is suggesting to have a great impact on cancer progression. AKR1B1 …
but growing evidence is suggesting to have a great impact on cancer progression. AKR1B1 …
PFKP signaling at a glance: an emerging mediator of cancer cell metabolism
Abstract Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an
allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis …
allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis …
Esophageal cancer epigenomics and integrome analysis of genome-wide methylation and expression in high risk northeast Indian population
Esophageal cancer is a major global health burden with a strong host–environment
interaction component and epigenomics underpinnings that remain to be elucidated further …
interaction component and epigenomics underpinnings that remain to be elucidated further …
Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4
DNA methylation is implicated in the acquisition of malignant phenotypes, and the use of
epigenetic modulating drugs is a promising anti-cancer therapeutic strategy. 5-aza …
epigenetic modulating drugs is a promising anti-cancer therapeutic strategy. 5-aza …
Genome-wide DNA methylation profiles of low-and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma
Background Abnormal DNA methylation is a hallmark of human cancers and may be a
promising biomarker for early diagnosis of human cancers. However, the majority of DNA …
promising biomarker for early diagnosis of human cancers. However, the majority of DNA …
Schistosomiasis induces persistent DNA methylation and tuberculosis-specific immune changes
Epigenetic mechanisms, such as DNA methylation, determine immune cell phenotype. To
understand the epigenetic alterations induced by helminth coinfections, we evaluated the …
understand the epigenetic alterations induced by helminth coinfections, we evaluated the …