[HTML][HTML] Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential

A Kazanets, T Shorstova, K Hilmi, M Marques… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However,
there are a number of universal aberrations common to all cancers, one of these being the …

DNA methylation biomarkers for noninvasive detection of triple‐negative breast cancer using liquid biopsy

M Manoochehri, N Borhani… - … Journal of Cancer, 2023 - Wiley Online Library
Noninvasive detection of aberrant DNA methylation could provide invaluable biomarkers for
earlier detection of triple‐negative breast cancer (TNBC) which could help clinicians with …

Aberrant WNT/CTNNB1 signaling as a therapeutic target in human breast cancer: weighing the evidence

EH Van Schie, RE Van Amerongen - Frontiers in cell and …, 2020 - frontiersin.org
WNT signaling is crucial for tissue morphogenesis during development in all multicellular
animals. After birth, WNT/CTNNB1 responsive stem cells are responsible for tissue …

DNA hypermethylation during tuberculosis dampens host immune responsiveness

AR DiNardo, K Rajapakshe… - The Journal of …, 2020 - Am Soc Clin Investig
Mycobacterium tuberculosis (M. tuberculosis) has coevolved with humans for millennia and
developed multiple mechanisms to evade host immunity. Restoring host immunity in order to …

Role of aldo‐keto reductase family 1 member B1 (AKR1B1) in the cancer process and its therapeutic potential

R Khayami, SR Hashemi… - Journal of cellular and …, 2020 - Wiley Online Library
The role of aldo‐keto reductase family 1 member B1 (AKR1B1) in cancer is not totally clear
but growing evidence is suggesting to have a great impact on cancer progression. AKR1B1 …

PFKP signaling at a glance: an emerging mediator of cancer cell metabolism

L Lang, R Chemmalakuzhy, C Shay, Y Teng - Reviews on Biomarker …, 2019 - Springer
Abstract Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an
allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis …

Esophageal cancer epigenomics and integrome analysis of genome-wide methylation and expression in high risk northeast Indian population

V Singh, LC Singh, M Vasudevan… - Omics: a journal of …, 2015 - liebertpub.com
Esophageal cancer is a major global health burden with a strong host–environment
interaction component and epigenomics underpinnings that remain to be elucidated further …

Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4

M Vernier, S McGuirk, CR Dufour, L Wan… - Oncogene, 2020 - nature.com
DNA methylation is implicated in the acquisition of malignant phenotypes, and the use of
epigenetic modulating drugs is a promising anti-cancer therapeutic strategy. 5-aza …

Genome-wide DNA methylation profiles of low-and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma

J Fan, J Li, S Guo, C Tao, H Zhang, W Wang… - Clinical …, 2020 - Springer
Background Abnormal DNA methylation is a hallmark of human cancers and may be a
promising biomarker for early diagnosis of human cancers. However, the majority of DNA …

Schistosomiasis induces persistent DNA methylation and tuberculosis-specific immune changes

AR DiNardo, T Nishiguchi, EM Mace… - The Journal of …, 2018 - journals.aai.org
Epigenetic mechanisms, such as DNA methylation, determine immune cell phenotype. To
understand the epigenetic alterations induced by helminth coinfections, we evaluated the …