Traditional cancer therapy methods, especially those directed against specific intracellular
targets or signaling pathways, are not powerful enough to overcome tumor heterogeneity …

Metformin has been a long-standing prescribed drug for treatment of type 2 diabetes (T2D)
and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are …

Glioblastoma is acknowledged as the most aggressive cerebral tumor in adults. However,
the efficacy of current standard therapy is seriously undermined by drug resistance and …

Surgery is the primary method to treat malignant melanoma; however, the residual
microtumors that cannot be resected completely often trigger tumor recurrence, causing …

Radiation-induced ototoxicity is associated with inflammation response and excessive
reactive oxygen species in the cochlea. However, the effectiveness of many drugs in clinical …

Glioblastoma (GBM) is a highly aggressive brain tumor associated with limited therapeutic
options and a poor prognosis. CXCR3, a chemokine receptor, serves dual autocrine …

Bacteria and bacterial components possess multifunctional properties, making them
attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent …

Clostridium novyi-NT (C. novyi-NT) is an anaerobic bacterium that can be used for targeted
cancer therapy because it germinates selectively in the hypoxic regions of tumor tissues …

Immunotherapy is regarded as one of the most promising approaches for treating tumors,
with a multitude of immunotherapeutic thoughts currently under consideration for the lethal …

The recurrent nature of glioblastoma negatively impacts conventional treatment strategies
leading to a growing need for nanomedicine. Nanotherapeutics, an approach designed to …