Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention
VS Neergheen, T Bahorun, EW Taylor, LS Jen… - Toxicology, 2010 - Elsevier
Natural phytochemicals derived from dietary sources or medicinal plants have gained
significant recognition in the potential management of several human clinical conditions …
significant recognition in the potential management of several human clinical conditions …
Gap junctions as targets for cancer chemoprevention and chemotherapy
JE Trosko, RJ Ruch - Current Drug Targets, 2002 - ingentaconnect.com
The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …
[图书][B] Fundamentals of Oncology, revised and expanded
HC Pitot - 2002 - taylorfrancis.com
Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …
Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor
E De Vuyst, E Decrock, M De Bock… - Molecular biology of …, 2007 - Am Soc Cell Biol
Gap junction (GJ) channels are formed by two hemichannels (connexons), each contributed
by the cells taking part in this direct cell–cell communication conduit. Hemichannels that do …
by the cells taking part in this direct cell–cell communication conduit. Hemichannels that do …
A role for heterologous gap junctions between melanoma and endothelial cells in metastasis
A Ito, F Katoh, TR Kataoka, M Okada… - The Journal of …, 2000 - Am Soc Clin Investig
F10 and BL6 sublines of B16 mouse melanoma cells are metastatic after intravenous
injection, but only BL6 cells are metastatic after subcutaneous injection. We found that …
injection, but only BL6 cells are metastatic after subcutaneous injection. We found that …
Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment
E Leithe, E Rivedal - Journal of Biological Chemistry, 2004 - ASBMB
Gap junctions are specialized plasma membrane domains enriched in connexin proteins
that form channels between adjacent cells. Gap junctions are highly dynamic, and …
that form channels between adjacent cells. Gap junctions are highly dynamic, and …
Gap‐junction disassembly and connexin 43 dephosphorylation induced by 18β‐glycyrrhetinic acid
X Guan, S Wilson, KK Schlender… - … in cooperation with the …, 1996 - Wiley Online Library
Gap‐junction channels connect the interiors of adjacent cells and can be arranged into
aggregates or plaques consisting of hundreds to thousands of channel particles. The …
aggregates or plaques consisting of hundreds to thousands of channel particles. The …
Pretreatment with eicosapentaenoic acid prevented hypoxia/reoxygenation-induced abnormality in endothelial gap junctional intercellular communication through …
YW Zhang, I Morita, XS Yao, S Murota - Prostaglandins, Leukotrienes and …, 1999 - Elsevier
Eicosapentaenoic acid (EPA) may protect against atherosclerotic disease, and modulation
of endothelium function is one possible mechanism. Hypoxia/reoxygenation (H/R) is a …
of endothelium function is one possible mechanism. Hypoxia/reoxygenation (H/R) is a …
The ε subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation
Gap junctions (GJs), composed of connexins, are intercellular channels ensuring electric
and metabolic coupling between cardiomyocytes. We have shown previously that an …
and metabolic coupling between cardiomyocytes. We have shown previously that an …
Carbon nanotubes instruct physiological growth and functionally mature syncytia: nongenetic engineering of cardiac myocytes
V Martinelli, G Cellot, FM Toma, CS Long… - ACS …, 2013 - ACS Publications
Myocardial tissue engineering currently represents one of the most realistic strategies for
cardiac repair. We have recently discovered the ability of carbon nanotube scaffolds to …
cardiac repair. We have recently discovered the ability of carbon nanotube scaffolds to …