Epithelial–mesenchymal transition in human cancer: comprehensive reprogramming of metabolism, epigenetics, and differentiation
L Li, W Li - Pharmacology & therapeutics, 2015 - Elsevier
The epithelial–mesenchymal transition (EMT) is a developmental process that is important
for embryogenesis, wound healing, organ fibrosis, and cancer metastasis. Cancer …
for embryogenesis, wound healing, organ fibrosis, and cancer metastasis. Cancer …
[HTML][HTML] The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation
MicroRNAs are frequently deregulated in cancer. Here we show that miR-22 is upregulated
in myelodysplastic syndrome (MDS) and leukemia and its aberrant expression correlates …
in myelodysplastic syndrome (MDS) and leukemia and its aberrant expression correlates …
[HTML][HTML] Understanding metabolic regulation and its influence on cell physiology
CM Metallo, MG Vander Heiden - Molecular cell, 2013 - cell.com
Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last
century, our knowledge of metabolic pathway architecture and the genomic landscape of …
century, our knowledge of metabolic pathway architecture and the genomic landscape of …
Tumour predisposition and cancer syndromes as models to study gene–environment interactions
Cell division and organismal development are exquisitely orchestrated and regulated
processes. The dysregulation of the molecular mechanisms underlying these processes …
processes. The dysregulation of the molecular mechanisms underlying these processes …
[HTML][HTML] Mutant IDH1 downregulates ATM and alters DNA repair and sensitivity to DNA damage independent of TET2
Mutations in the isocitrate dehydrogenase-1 gene (IDH1) are common drivers of acute
myeloid leukemia (AML) but their mechanism is not fully understood. It is thought that IDH1 …
myeloid leukemia (AML) but their mechanism is not fully understood. It is thought that IDH1 …
Connections between TET proteins and aberrant DNA modification in cancer
DNA methylation has been linked to aberrant silencing of tumor suppressor genes in cancer,
and an imbalance in DNA methylation–demethylation cycles is intimately implicated in the …
and an imbalance in DNA methylation–demethylation cycles is intimately implicated in the …
IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism
AR Grassian, SJ Parker, SM Davidson, AS Divakaruni… - Cancer research, 2014 - AACR
Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of
cancer, but the metabolic consequences of these genetic changes are not fully understood …
cancer, but the metabolic consequences of these genetic changes are not fully understood …
Notch signaling: switching an oncogene to a tumor suppressor
The Notch signaling pathway is a regulator of self-renewal and differentiation in several
tissues and cell types. Notch is a binary cell-fate determinant, and its hyperactivation has …
tissues and cell types. Notch is a binary cell-fate determinant, and its hyperactivation has …
[HTML][HTML] Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
AM Fontebasso, J Schwartzentruber… - Acta …, 2013 - Springer
Recurrent mutations affecting the histone H3. 3 residues Lys27 or indirectly Lys36 are
frequent drivers of pediatric high-grade gliomas (over 30% of HGGs). To identify additional …
frequent drivers of pediatric high-grade gliomas (over 30% of HGGs). To identify additional …
Molecular pathways: isocitrate dehydrogenase mutations in cancer
O Clark, K Yen, IK Mellinghoff - Clinical Cancer Research, 2016 - AACR
IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to α-
ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP+. Mutations in …
ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP+. Mutations in …