Cisplatin is a highly effective antitumor drug generally used in the treatment of solid
malignant tumors. However, cisplatin causes severe side effects such as bone marrow …

Cisplatin is widely used for the treatment of a number of solid malignant tumors. However,
ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for …

Central and especially peripheral neurotoxicities due to systemic antineoplastic therapy are
common and often dose-limiting side-effects. In patients with chemotherapy (ChT)-induced …

Cisplatin is a highly effective antineoplastic agent used to treat solid tumors. Unfortunately,
the administration of this drug leads to significant side effects, including ototoxicity …

Despite the high incidence of inner ear disorders, there are still no dedicated medications on
the market. Drugs are currently administered by the intratympanic route, the safest way to …

Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular
cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has …

Background Ototoxicity is one of the major side effects of platinum-based chemotherapy,
especially cisplatin therapy. To date, no FDA approved agents to alleviate or prevent this …

Aminoglycoside, a medicinal category of antibiotics, are used in treatment of Gram-negative
bacterial infections. Although they are the most widely-used antibiotics due to their high …

Antimicrobials are a widely used class of medications, but several of them are associated
with neurological and psychiatric side effects. The exact incidence of neurotoxicity with anti …

Over the past two decades, significant technological advances have facilitated the
identification of hundreds of genes associated with hearing loss. Variants in many of these …