[HTML][HTML] Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm

S Jana, M Hu, M Shen, Z Kassiri - Experimental & molecular medicine, 2019 - nature.com
Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …

MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm

Y Li, W Wang, L Li, RA Khalil - Life sciences, 2020 - Elsevier
Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by
progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture …

Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm

B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …

The role of ADAMTS-4 in atherosclerosis and vessel wall abnormalities

R Novak, S Hrkac, G Salai, J Bilandzic, L Mitar… - Journal of vascular …, 2022 - karger.com
Extracellular matrix proteins are regulated by metzincin proteases, like the disintegrin
metalloproteinases with thrombospondin motifs (ADAMTS) family members. This review …

[HTML][HTML] KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction

G Zhao, Z Chang, Y Zhao, Y Guo, H Lu, W Liang… - JCI insight, 2021 - ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease.
Endothelial cell (EC) dysfunction is implicated in AAA. Our group recently demonstrated that …

MiRNA‐181a is a novel regulator of aldosterone–mineralocorticoid receptor‐mediated cardiac remodelling

A Garg, A Foinquinos, M Jung… - European Journal of …, 2020 - Wiley Online Library
Aim The aldosterone–mineralocorticoid receptor (Aldo–MR) pathway is activated during
cardiac stress, such as hypertension, myocardial infarction (MI), and heart failure. The …

MiR‐126a‐5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS‐4 expression

L Li, W Ma, S Pan, Y Li, H Wang… - Journal of Cellular …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) is a serious vascular disease featured by inflammatory
infiltration in aortic wall, aortic dilatation and extracellular matrix (ECM) degradation …

ADAM (a disintegrin and metalloproteinase) 15 deficiency exacerbates Ang II (angiotensin II)–Induced aortic remodeling leading to abdominal aortic aneurysm

S Jana, M Chute, M Hu, G Winkelaar… - … and Vascular Biology, 2020 - Am Heart Assoc
Objective: ADAM (a disintegrin and metalloproteinase) 15—a membrane-bound
metalloprotease from the ADAM (disintegrin and metalloproteinase) family—has been linked …

[HTML][HTML] Aortic dilatation in patients with bicuspid aortic valve

J Wang, W Deng, Q Lv, Y Li, T Liu, M Xie - Frontiers in Physiology, 2021 - frontiersin.org
Bicuspid aortic valve (BAV) is the most common congenital cardiac abnormality. BAV aortic
dilatation is associated with an increased risk of adverse aortic events and represents a …

[HTML][HTML] Targeting the extracellular matrix in abdominal aortic aneurysms using molecular imaging insights

L Adams, J Brangsch, B Hamm, MR Makowski… - International Journal of …, 2021 - mdpi.com
This review outlines recent preclinical and clinical advances in molecular imaging of
abdominal aortic aneurysms (AAA) with a focus on molecular magnetic resonance imaging …