Cannabis sativa is the source of a unique set of compounds known collectively as plant
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …

Objective This review of the scientific literature examines the potential adult sequelae of
exposure to cannabis and related synthetic cannabinoids in adolescence. We examine the …

This study examines the current knowledge of physiological and clinical effects of
tetrahydrocannabinol (THC) and cannabidiol (CBD) and presents a rationale for their …

The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …

Mandarin translation of abstract Medicines that activate cannabinoid CB1 and CB2 receptor
are already in the clinic. These are Cesamet®(nabilone), Marinol®(dronabinol; Δ9 …

ABSTRACT A major finding—that (–)‐trans‐Δ9‐tetrahydrocannabinol (Δ9‐THC) is largely
responsible for the psychotropic effects of cannabis—prompted research in the 1970s and …

Background Mixed cannabinoid receptor 1 and 2 (CB 1 and CB 2) agonists such as Δ 9-
tetrahydrocannabinol (Δ 9-THC) can produce tolerance, physical withdrawal, and unwanted …

There are at least 2 types of cannabinoid receptor, CB 1 and CB 2, both G protein coupled.
CB 1 receptors are expressed predominantly at nerve terminals and mediate inhibition of …

Paracetamol (acetaminophen) is one of the most commonly used drugs for the treatment of
pain and fever in children, both at home and in the clinic, and is now also found in the …

The chronic constriction injury model is a rat model of neuropathic pain based on a
unilateral loose ligation of the sciatic nerve. The aim of the present study was to test its …