Abstract This Consensus Statement summarizes recommendations for clinical diagnosis,
investigation and management of patients with Silver–Russell syndrome (SRS), an …

The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Context: Central precocious puberty (CPP) results from premature activation of the
hypothalamic–pituitary–gonadal axis. Few genetic causes of CPP have been identified, with …

Pubertal timing is regulated by the complex interplay of genetic, environmental, nutritional
and epigenetic factors. Criteria for determining normal pubertal timing, and thus the …

Central precocious puberty (CPP) results from early activation of the hypothalamic‐pituitary‐
gonadal (HPG) axis. The current state of knowledge of the complex neural network acting at …

Objective: This retrospective study aimed to evaluate children observed for suspected
precocious puberty in 5 Italian centers of Pediatric Endocrinology during the first wave of …

A 7 year old girl presents with history of body odour. She is tall for her age and her mother
reports noticeable breast development and pubic hair growth over the last six months. The …

The family of Poly (A)-binding proteins (PABPs) regulates the stability and translation of
messenger RNAs (mRNAs). Here we reported that the three members of PABPs, including …

Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from
Anemarrhena asphodeloides Bunge. Among the various phytosteroids present …