Background The treatment of constitutional delay of growth and puberty (CDGP) is an
underinvestigated area in adolescent medicine. We tested the hypothesis that peroral …

Objective Isolated central precocious puberty (CPP) includes sporadic, familial and adoption-
related forms, and the characterization of its etiology is challenging. This study investigated …

Context: Loss-of-function mutations in the coding region of MKRN3, a maternally imprinted
gene at chromosome 15q11. 2, are a common cause of familial central precocious puberty …

Tall stature is defined as a height of more than 2 standard deviations (sd) above average for
same sex and age. Tall individuals are usually referred to endocrinologists so that hormonal …

Neuroimaging is a key tool in the diagnostic process of various clinical conditions, especially
in pediatric endocrinology. Thanks to continuous and remarkable technological …

Puberty, which in humans is considered to include both gonadarche and adrenarche, is the
period of becoming capable of reproducing sexually and is recognized by maturation of the …

Objective To evaluate the psychiatric diagnoses, peer-victimization, quality of life, and
emotional and behavioral status of girls with central precocious puberty (CPP). Methods A …

Purpose Tall stature is defined as height greater than the threshold of more than 2 standard
deviations above the average population height for age, sex, and ethnicity. Many studies …

Makorin RING finger protein 3 (MKRN3) is a key inhibitor of the hypothalamic–pituitary–
gonadal axis. Loss-of-function mutations in MKRN3 cause familial and sporadic central …

Relative to the life history of other great apes, that of humans is characterized by early
weaning and short interbirth intervals (IBIs). We propose that in modern humans, birth until …