Schizophrenia is a debilitating psychiatric disorder that affects millions of people worldwide;
however, its etiology is poorly understood at the molecular and neurobiological levels. A …

The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …

Complement overactivation mediates microglial synapse elimination in neurological
diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but how …

Recent studies have reported that complement-related proteins modulate brain
development through regulating synapse processes in the cortex. CSMD3 belongs to a …

Schizophrenia (SCZ) is a complex, heritable and polygenic neuropsychiatric disease, which
disables the patients as well as decreases their life expectancy and quality of life. Common …

Background Gestational exposure to polychlorinated biphenyls (PCBs) has been associated
with elevated risk for neurodevelopmental disorders. Placental epigenetics may serve as a …

Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia.
The variation includes numbers of the increased C4A copy number, which predicts …

CUB and Sushi Multiple Domains 1 (CSMD1), a tumour suppressor gene, encodes a large
membrane-bound protein including a single transmembrane domain. This transmembrane …

Abstract CSMD1 (Cub and Sushi Multiple Domains 1) is a well-recognized regulator of the
complement cascade, an important component of the innate immune response. CSMD1 is …

Microglia, the resident brain immune cells, play a critical role in normal brain development,
and are impacted by the intrauterine environment, including maternal immune activation and …